ASSESSMENT OF EMBRYOTOXIC EFFECTS OF CADMIUM, LEAD AND COPPER ON Xenopus laevis

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dc.authoridGüngördü, Abbas/0000-0001-7770-0660
dc.authoridBirhanlı, Ayşe/0000-0003-0870-1226
dc.authoridOzmen, Murat/0000-0003-4378-0839
dc.authorwosidOZMEN, MURAT/A-4874-2009
dc.authorwosidGüngördü, Abbas/A-3009-2015
dc.authorwosidBirhanlı, Ayşe/ABH-3226-2020
dc.contributor.authorGungordu, Abbas
dc.contributor.authorBirhanli, Ayse
dc.contributor.authorOzmen, Murat
dc.date.accessioned2024-08-04T20:57:12Z
dc.date.available2024-08-04T20:57:12Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis work evaluated the effects of selected metals on embryos using Frog Embryo Teratogenesis Assay- Xenopus (FETAX). Besides FETAX parameters, changes in several biomarkers were studied as early signs of intoxication on Xenopus laevis tadpoles. The acute effects of metals were investigated by using the activity of the enzymes glutathione S-transferase (GST), glutathione reductase, acetylcholinesterase (AChE), carboxylesterase, lactate dehydrogenase, aspartate aminotranferase, and alanine aminotranferase. In the FETAX test, 96-h LC50s were determined as 1.6 mg/L, 96.1 mg/L, and 1.37 mg/L for Cd, Pb, and Cu, respectively. Also, teratogenic index (TI) of each metal was estimated as 1.1, 1.22, and 0.52 for Cd, Pb, and Cu, respectively. The TI showed that tested metals were not teratogenic in X. laevis embryos according to ASTM values. The comparison of selected metals on selected enzyme activities was expected to give useful indications for the proper use of biochemical responses as biomarkers.en_US
dc.description.sponsorshipInonu University [I.U.A.F. 2006-24]en_US
dc.description.sponsorshipThis study is a part of a comprehensive project that is supported by the Inonu University Research Fund (Project no: I.U.A.F. 2006-24). The authors wish to thank the supporting institution for their financial support of the project.en_US
dc.identifier.endpage2535en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue11en_US
dc.identifier.startpage2528en_US
dc.identifier.urihttps://hdl.handle.net/11616/102414
dc.identifier.volume19en_US
dc.identifier.wosWOS:000285076800009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFETAXen_US
dc.subjectXenopus laevisen_US
dc.subjectmalformationsen_US
dc.subjectmetalsen_US
dc.subjectbiomarkersen_US
dc.titleASSESSMENT OF EMBRYOTOXIC EFFECTS OF CADMIUM, LEAD AND COPPER ON Xenopus laevisen_US
dc.typeArticleen_US

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