The effect of melatonin against FK506 induced renal oxidative stress in rats
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Dosyalar
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
The effect of melatonin against FK506 induced renal oxidative stress in rats
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Nephrotoxicity is an important side effect of FK506 and oxidative stress has been considered as one of the
possible mechanisms. The present investigation examines the ability of melatonin to protect against FK506-induced renal
oxidative stress. Methods: Thirty rats were divided into 3 groups (n = 10 each group). Group A was the sham group. Group
B received 14 days FK506 (5 mg/kg/d, intraperitoneally [i.p.]) and group C received FK506 (5 mg/kg/d, i.p.) together with
melatonin (4 mg/kg, i.p.) for 14 days. Kidney tissues were harvested to determine the tissue levels of malondialdehyde
(MDA), total nitrite and nitric oxide (NO), tumor necrosis factor-a (TNF-a), and interleukin-6 (IL-6). Results: In group C,
the levels of TNF-a, IL-6, and NO were lower than in the group B (P < .01, P < .03, and P < .04, respectively) and although
MDA levels were lower than in group B, the differences were not statistically significant (P > .05). Conclusion: These results
suggest that melatonin has protective effect against FK506-induced renal oxidative stress.
Açıklama
Anahtar Kelimeler
Melatonin, Acrilimus, Renal oxidative stress
Kaynak
The effect of melatonin against FK506 induced renal oxidative stress in rats
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Scopus Q Değeri
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0
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0
Künye
Ara, C., Dirican, A., Ünal, B., Bay Karabulut, A., & Pişkin, T. (2011). The Effect Of Melatonin Against Fk506 İnduced Renal Oxidative Stress İn Rats. Surg Innov, 0–0.
