Neutrophil gelatinase-associated lipocalin reflects the severity of anemia without iron deficiency and secondary hyperparathyroidism in hemodialysis patients

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dc.authoridtaskapan, hulya/0000-0001-8736-4779
dc.authoridGozel, Nevzat/0000-0001-7326-6860
dc.authorwosidulu, ramazan/V-9751-2018
dc.authorwosidPembegul, Irem/HJA-2191-2022
dc.authorwosidtaskapan, hulya/ABI-7737-2020
dc.authorwosidDogukan, Ayhan/W-2518-2018
dc.authorwosidPembegul, Irem/AAB-6645-2022
dc.contributor.authorYigit, Irem Pembegul
dc.contributor.authorUlu, Ramazan
dc.contributor.authorGozel, Nevzat
dc.contributor.authorTaskapan, Hulya
dc.contributor.authorIlhan, Necip
dc.contributor.authorDogukan, Ayhan
dc.date.accessioned2024-08-04T21:00:02Z
dc.date.available2024-08-04T21:00:02Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Secondary hyperparathyroidism (SHPT) and anemia are the primary and most common complications in patients receiving hemodialysis (HD). Neutrophil gelatinase-associated lipocalin (NGAL) is a new marker to assess iron deficiency and manage iron therapy for HD patients. The aim of this study was to determine any association between serum NGAL level and anemia without iron deficiency in patients with SHPT on chronic HD. METHODS: Total of 61 SHPT patients on chronic HD were enrolled in the study and divided into 3 groups: mild SHPT group (n=17), moderate SHPT group (n=21), and severe SHPT group (n=23). Hemogram, biochemical assays, and level of ferritin, high sensitivity C-reactive protein (hs-CRP), and NGAL were evaluated in all groups. RESULTS: Serum NGAL level was significantly higher and hemoglobin (Hb) level was significantly lower in severe SHPT patients compared with both mild and moderate SHPT patients. Furthermore, in severe SHPT group, serum NGAL level was significantly positively correlated with serum parathyroid hormone (r=0.79; p=0.00) and hs-CRP (r=0.52; p=0.01) level and negatively correlated with serum Hb (r=-0.56; p=0.00) level. CONCLUSION: SHPT was important factor affecting anemia in HD patients. Even when iron deficiency anemia is excluded in patients with SHPT, there was significant negative correlation between serum NGAL and Hb.en_US
dc.identifier.doi10.14744/nci.2017.59002
dc.identifier.endpage42en_US
dc.identifier.issn2148-4902
dc.identifier.issue1en_US
dc.identifier.pmid28752141en_US
dc.identifier.startpage36en_US
dc.identifier.urihttps://doi.org/10.14744/nci.2017.59002
dc.identifier.urihttps://hdl.handle.net/11616/103748
dc.identifier.volume4en_US
dc.identifier.wosWOS:000408984000006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofNorthern Clinics of Istanbulen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnemiaen_US
dc.subjecthemodialysisen_US
dc.subjecthyperparathyroidismen_US
dc.subjectneutrophil gelatinase-associated lipocalinen_US
dc.titleNeutrophil gelatinase-associated lipocalin reflects the severity of anemia without iron deficiency and secondary hyperparathyroidism in hemodialysis patientsen_US
dc.typeArticleen_US

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