Effects of nutritional vitamin d supplementation on markers of bone and mineral metabolism in children with chronic kidney disease

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dc.contributor.authorLerch, Christian
dc.contributor.authorShroff, Rukshana
dc.contributor.authorWan, Mandy
dc.contributor.authorRees, Lesley
dc.date.accessioned2019-06-18T12:10:28Z
dc.date.available2019-06-18T12:10:28Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. We investigated the effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism, i.e. serum levels of fibroblast growth factor 23 (FGF23), Klotho, bone alkaline phosphatase (BAP) and sclerostin, in two cohorts with chronic kidney disease (CKD). Methods. In all, 80 vitamin D-deficient children were selected: 40 with mild to moderate CKD from the ERGO study, a randomized trial of ergocalciferol supplementation [ estimated glomerular filtration rate (eGFR) 55 mL/min/1.73 m(2)], and 40 with advanced CKD from the observational Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study (eGFR 24 mL/min/1.73 m2). In each study, vitamin D supplementation was started in 20 children and 20 matched children not receiving vitamin D served as controls. Measures were taken at baseline and after a median period of 8 months. Age- and gender-related standard deviation scores (SDSs) were calculated. Results. Before vitamin D supplementation, children in the ERGO study had normal FGF23 (median 0.31 SDS) and BAP (-0.10 SDS) but decreased Klotho and sclerostin (-0.77 and -1.04 SDS, respectively), whereas 4C patients had increased FGF23 (3.87 SDS), BAP (0.78 SDS) and sclerostin (0.76 SDS) but normal Klotho (-0.27 SDS) levels. Vitamin D supplementation further increased FGF23 in 4C but not in ERGO patients. Serum Klotho and sclerostin normalized with vitamin D supplementation in ERGO but remained unchanged in 4C patients. BAP levels were unchanged in all patients. In the total cohort, significant effects of vitamin D supplementation were noted for Klotho at eGFR 40-70 mL/min/1.73 m(2). Conclusions. Vitamin D supplementation normalized Klotho and sclerostin in children with mild to moderate CKD but further increased FGF23 in advanceden_US
dc.identifier.citationLerch, C, Shroff, R, Wan, M, Rees, L. (2018). Effects of nutritional vitamin d supplementation on markers of bone and mineral metabolism in children with chronic kidney disease. Cilt:33, Sayı:12, 2208-2217 ssen_US
dc.identifier.endpage2217en_US
dc.identifier.issue12en_US
dc.identifier.startpage2208en_US
dc.identifier.urihttps://hdl.handle.net/11616/11428
dc.identifier.volume33en_US
dc.language.isoenen_US
dc.publisherNephrology dıalysıs transplantatıonen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbone and mineral metabolismen_US
dc.subjectchildrenen_US
dc.subjectchronic kidney diseaseen_US
dc.subjectvitamin D deficiencyen_US
dc.subjectvitamin D supplementationen_US
dc.titleEffects of nutritional vitamin d supplementation on markers of bone and mineral metabolism in children with chronic kidney diseaseen_US
dc.typeArticleen_US

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