Elevated monocyte to high-density lipoprotein cholesterol ratio and endothelial dysfunction inbehcet disease
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SAGE PUBLICATIONS INC, 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Behcet disease (BD) is a multisystemic disorder characterized by endothelial dysfunction and inflammation. Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a recently emerged indicator of inflammation and oxidative stress. Sixty patients with BD and 50 control individuals were included to investigate the relationship between MHR and endothelial dysfunction. Endothelial function was assessed by flow- and nitroglycerin-mediated dilatation technique (FMD and NMD, respectively). Serum high-sensitivity C-reactive protein (hsCRP) levels were measured in all study participants. The MHR and hsCRP levels were significantly higher in patients with active BD than in controls. Brachial artery FMD was significantly lower in patients with active BD than in controls. Brachial artery NMD was similar between groups. There was a strong inverse correlation between MHR and FMD and a strong positive correlation between MHR and serum hsCRP levels. Thus, elevated MHR may be a useful marker reflecting impaired endothelial function and systemic inflammation in patients with BD.
Açıklama
Anahtar Kelimeler
Markers, Hdl, Inflammatıon, Involvement
Kaynak
Angıology
WoS Q Değeri
Scopus Q Değeri
Cilt
69
Sayı
1
Künye
Açıkgöz, N. Kurtoğlu, E. Yağmur, J. Kapıcıoğlu, Y. Cansel, M. Ermiş, N. (2018). Elevated monocyte to high-density lipoprotein cholesterol ratio and endothelial dysfunction inbehcet disease. Cilt:69 Sayı:1, 65-70 ss.
