Can serum interleukin 34 levels be used as an indicator for the prediction and prognosis of COVID-19?

Basit Öğe Kaydı
dc.authoridKarahan, Doğu/0000-0002-5387-2000
dc.authorwosidKarahan, Doğu/HJI-2769-2023
dc.contributor.authorKarahan, Dogu
dc.contributor.authorBolayir, Hasan Ata
dc.contributor.authorBolayir, Asli
dc.contributor.authorDemir, Bilgehan
dc.contributor.authorOtlu, Oender
dc.contributor.authorErdem, Mehmet
dc.contributor.authorPerera, Nilanka
dc.date.accessioned2024-08-04T20:57:19Z
dc.date.available2024-08-04T20:57:19Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective Interleukin 34 (IL-34) is a molecule whose expression is increased in conditions such as autoimmune disorders, inflammation, and infections. Our study aims to determine the role of IL-34 in the diagnosis, follow-up, and prognosis of Coronavirus Disease-19 (COVID-19).Method A total of 80 cases were included in the study as 40 COVID-19 positive patient groups and 40 COVID-19 negative control groups. The COVID-19-positive group consisted of 20 intensive-care unit (ICU) patients and 20 outpatients. Serum IL-34, c-reactive protein (CRP), ferritin, D-dimer, troponin I, hemogram, and biochemical parameters of the cases were studied and compared between groups.Results IL-34 levels were significantly higher in the COVID-19-positive group than in the negative group. IL-34 levels increased in correlation with CRP in predicting the diagnosis of COVID-19. IL-34 levels higher than 31.75 pg/m predicted a diagnosis of COVID-19. IL-34 levels did not differ between the outpatient and ICU groups in COVID-19-positive patients. IL-34 levels were also not different between those with and without lung involvement.Conclusion While IL-34 levels increased in COVID-19-positive patients and were successful in predicting the diagnosis of COVID-19, it was not found to be significant in determining lung involvement, risk of intensive care hospitalization, and prognosis. The role of IL-34 in COVID-19 deserves further evaluation.en_US
dc.identifier.doi10.1371/journal.pone.0302002
dc.identifier.issn1932-6203
dc.identifier.issue4en_US
dc.identifier.pmid38626032en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0302002
dc.identifier.urihttps://hdl.handle.net/11616/102520
dc.identifier.volume19en_US
dc.identifier.wosWOS:001205750000120en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThrombosisen_US
dc.subjectCytokineen_US
dc.subjectFibrosisen_US
dc.titleCan serum interleukin 34 levels be used as an indicator for the prediction and prognosis of COVID-19?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu