Histopathological Evaluation of the Effects of Melatonin as a Protectant Against Oropharyngeal Mucositis Induced by Radiation Therapy in a Pinealectomy Model in Rats

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dc.authoridErsoy, Pamir Eren/0000-0002-6148-8527
dc.authorwosidErkal, Haldun Sukru/AAC-8209-2019
dc.authorwosidErsoy, Pamir Eren/T-6339-2019
dc.contributor.authorOzturk, Aysen S.
dc.contributor.authorErkal, Haldun S.
dc.contributor.authorMemis, Leyla
dc.contributor.authorOztanir, Namik
dc.contributor.authorErsoy, Eren
dc.contributor.authorAykol, Suekrue
dc.contributor.authorEgehan, Ibrahim
dc.date.accessioned2024-08-04T20:58:58Z
dc.date.available2024-08-04T20:58:58Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study presents the histopathological evaluation of the effects of melatonin as a protectant against oropharyngeal mucositis induced by radiation therapy in a pinealectomy model in rats. Thirty-two Wistar rats were divided into four groups. The rats in Group 1 underwent pinealectomy, received melatonin and underwent radiation therapy. The rats in Group 2 underwent pinealectomy, received no melatonin and underwent radiation therapy. The rats in Group 3 underwent sham pinealectomy, received melatonin and underwent radiation therapy. The rats in Group 4 underwent sham pinealectomy, received no melatonin and underwent radiation therapy. The rats underwent euthanasia at six days following radiation therapy. The oropharyngeal tissues were dissected and histopathological evaluation was performed regarding the effects of melatonin as a protectant against oropharyngeal mucositis induced by radiation therapy. Mean item scores for vascular calibration were 2.3 points for Group 1, 2.3 points for Group 2, 1.8 points for Group 3 and 2.1 points for Group 4 (p= 0.44). Mean item scores for vascular permeability were 2.4 points for Group 1, 2.4 points for Group 2, 2.0 points for Group 3 and 2.1 points for Group 4 (p= 0.61). Mean item scores for leukocyte emigration were 2.0 points for Group 1, 2.0 points for Group 2, 1.3 points for Group 3 and 1.6 points for Group 4 (p= 0.02). Mean overall scores for oropharyngeal mucositis were 6.6 points for Group 1, 6.6 points for Group 2, 5.1 points for Group 3 and 5.8 points for Group 4 (p= 0.15). This study elicits the potential effects of melatonin as a protectant against oropharyngeal mucositis induced by radiation therapy.en_US
dc.identifier.endpage94en_US
dc.identifier.issn1306-133X
dc.identifier.issue2en_US
dc.identifier.startpage88en_US
dc.identifier.urihttps://hdl.handle.net/11616/103308
dc.identifier.volume19en_US
dc.identifier.wosWOS:000271595500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAkad Doktorlar Yayinevien_US
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadiation injuryen_US
dc.subjectMucous membraneen_US
dc.subjectMelatoninen_US
dc.subjectPinealectomyen_US
dc.titleHistopathological Evaluation of the Effects of Melatonin as a Protectant Against Oropharyngeal Mucositis Induced by Radiation Therapy in a Pinealectomy Model in Ratsen_US
dc.typeArticleen_US

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