BIOCHEMICAL EFFECT EVALUATION OF MICROBIAL CHONDROITIN SULPHATE IN EXPERIMENTAL KNEE OSTEOARTHRITIS MODEL

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dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authoridUnver, Tuba/0000-0002-8655-2716
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.authorwosidUnver, Tuba/ABI-6440-2020
dc.contributor.authorErenler, Ayse Sebnem
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorSevimli, Resit
dc.contributor.authorGeckil, Hikmet
dc.contributor.authorAkpolat, Nusret
dc.contributor.authorUnver, Tuba
dc.contributor.authorOtlu, Onder
dc.date.accessioned2024-08-04T20:57:15Z
dc.date.available2024-08-04T20:57:15Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOsteoarthritis (OA) is the most common chronic joint disease, primarily due to aging. Chondroitin sulfate (CS) is a glycosaminoglycan (GAG) commonly used to treat osteoarthritis. CS can delay the progression of pathology or reverse morphological changes in joint structure. Traditionally CS is produced from animal sources. However, due to different reasons such as contamination, ecological risk, and the possibility of infectious diseases, the trend towards microbial sources has increased because of its advantages such as purer, more antiallergic, and lower Molecular Weight (MW) than animal sources. Biochemical analysis of Microbial CS (MCS), which is a new and significant alternative as a source of CS in the OA healing process, has not been evaluated in the literature yet. This study was designed to analyze the biochemical effects of MCS produced by our team from a microbial source, with an MW value of 269 Daltons, on the osteoarthritis healing process compared to the commercial foiut. We aim to reach data that MCS has a higher antioxidant effect than animal -sourced CS, and in this way, it is a more suitable production for the treatment of osteoarthritis. In this study, knee osteoarthritis was surgically induced in experimental rabbits; and TGF113, CAT, MPO, TOS, and OSI parameters measured in blood samples before the operation and after the healing period were analyzed comparatively. After the surgical application, the rabbits were randomly divided into three groups: control, animal -sourced CS, and E. cull sourced. MCS. The standard rabbit diet was administered daily to 10 rabbits in Group 1 (control), and. CS and MCS were applied daily to the other groups as 17 mg/kg for 12 weeks. Blood samples were taken from rabbits at the 12th week after surgery, and TGF-113, CAT, MPO, TOS, and OSI parameters were biochemically evaluated. This study has confirmed that the antioxidant properties of MCS and data on its effectiveness in controlling oxidative stress compared to animal -sourced CS. Based on these results, it can be concluded that MCS has a significant potency of nutraceutical and therapeutic agents for OA treatment.en_US
dc.description.sponsorshipTUBITAK [1001 (215S-861)]en_US
dc.description.sponsorshipThis study was supported by TUBITAK 1001 (215S-861).en_US
dc.identifier.endpage+en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue1en_US
dc.identifier.startpage510en_US
dc.identifier.urihttps://hdl.handle.net/11616/102474
dc.identifier.volume31en_US
dc.identifier.wosWOS:000736347700054en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChondroitin sulfateen_US
dc.subjectMicrobial chondroitin sulfateen_US
dc.subjectOsteoarthritisen_US
dc.titleBIOCHEMICAL EFFECT EVALUATION OF MICROBIAL CHONDROITIN SULPHATE IN EXPERIMENTAL KNEE OSTEOARTHRITIS MODELen_US
dc.typeArticleen_US

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