Frequency of hereditary thrombophilia, anticoagulant activity, and homocysteine levels in patients with hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome

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dc.authorwosidSimsek, Yavuz/AAH-9894-2021
dc.contributor.authorDogan, Ovgu Ozkan
dc.contributor.authorSimsek, Yavuz
dc.contributor.authorCelen, Sevki
dc.contributor.authorDanisman, Nuri
dc.date.accessioned2024-08-04T20:58:52Z
dc.date.available2024-08-04T20:58:52Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The purpose of this study was to investigate the correlations between thrombophilic mutations, anticoagulant activity and hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome. Material and Methods: Twenty-five healthy pregnant women (control group) and 34 patients with HELLP syndrome (study group) were included in the study between April 2007 and January 2008. Homocysteine levels and activities of protein C, protein S and antithrombin III of the groups were compared. Frequency of factor V Leiden mutation, prothrombin 20210A mutation and C677 T mutation of methylenetetrahydrofolate reductase gene were also compared. Results: Frequencies of thrombophilic gene mutations of the two groups were not significantly different. Homocysteine levels were significantly higher in the study group. Protein C and protein S deficiencies of the two groups were similar. Antithrombin III deficiency was statistically higher in the patients with HELLP syndrome. Conclusion: The frequency of antithrombin III deficiency and homocysteine levels were higher in the patients with HELLP syndrome; however, there was no positive relationship between hereditary thrombophilic mutations and the disease. Larger prospective studies are needed to validate our findings.en_US
dc.identifier.doi10.1111/j.1447-0756.2010.01397.x
dc.identifier.endpage533en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue6en_US
dc.identifier.pmid21375667en_US
dc.identifier.startpage527en_US
dc.identifier.urihttps://doi.org/10.1111/j.1447-0756.2010.01397.x
dc.identifier.urihttps://hdl.handle.net/11616/103237
dc.identifier.volume37en_US
dc.identifier.wosWOS:000291276100008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantithrombin IIIen_US
dc.subjecthemolysisen_US
dc.subjectelevated liver functions and low thrombocyte count (HELLP) syndromeen_US
dc.subjectprotein Cen_US
dc.subjectprotein Sen_US
dc.subjectthrombophiliaen_US
dc.titleFrequency of hereditary thrombophilia, anticoagulant activity, and homocysteine levels in patients with hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndromeen_US
dc.typeArticleen_US

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