Influence of Liver Transplantation on Neuropsychiatric Manifestations of Wilson Disease

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dc.authorid131278en_US
dc.authorid28465en_US
dc.authorid146962en_US
dc.authorid110105en_US
dc.contributor.authorTardu, Ali
dc.contributor.authorKaragül, Servet
dc.contributor.authorErtuğrul, İsmail
dc.contributor.authorİnce, Volkan
dc.contributor.authorKırmızı, Serdar
dc.contributor.authorÜnal, Bülent
dc.contributor.authorIşık, Burak
dc.contributor.authorKayaalp, Cüneyt
dc.contributor.authorYılmaz, Sezai
dc.date.accessioned2017-11-07T06:29:50Z
dc.date.available2017-11-07T06:29:50Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.descriptionTransplantation Proceedingsen_US
dc.description.abstractObjectives. This study sought to evaluate the effect of liver transplantation on the neuropsychological manifestations of Wilson disease. Materials and Methods. Nine of 42 Wilson disease patients had neuropsychological symptoms before liver transplantation. They were 7 male and 2 female subjects with a median age of 19 years (range 10 to 25). They were analyzed for their preoperative and postoperative hepatic, neurological, and psychological scores described by the Unified Wilson Disease Rating Scale after a mean 36.6 months of follow-up. Results. Preoperative mean Model for End-Stage Liver Disease and Child-Pugh scores were 18.3 (range 15 to 26) and 8.9 (range 6 to 12), respectively. One patient had acute postoperative ischemic stroke unrelated to Wilson disease and was excluded from the statistical analysis. Preoperative and postoperative hepatic, neurological, and psychological scores of the remaining 8 patients were 7.4 2.3 vs 2.4 1.3 (P ¼ .0005), 17.7 11.7 vs 12.7 12.5 (P ¼ .055), and 9.0 1.7 vs 7.0 2.1 (P ¼ .033). Conclusions. Liver transplantation for Wilson disease can provide some improvement of the neuropsychological symptoms in addition to the hepatic recovery.en_US
dc.identifier.citationYagci, M., Tardu, A., Karagul, S., Ertugrul, İ., İnce, V., Kırmızı, S., … Yılmaz, S. (2015). Influence Of Liver Transplantation On Neuropsychiatric Manifestations Of Wilson Disease. Transplantation Proceedings, 47(5), 1469–1473.en_US
dc.identifier.doi10.1016/j.transproceed.2015.04.017en_US
dc.identifier.endpage1473en_US
dc.identifier.issue5en_US
dc.identifier.startpage1469en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0041134515003425
dc.identifier.urihttps://hdl.handle.net/11616/7832
dc.identifier.volume47en_US
dc.language.isoenen_US
dc.publisherTransplantation Proceedingsen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleInfluence of Liver Transplantation on Neuropsychiatric Manifestations of Wilson Diseaseen_US
dc.typeArticleen_US

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