Brain MR spectroscopy in children with a history of rheumatic fever with a special emphasis on neuropsychiatric complications
Yükleniyor...
Dosyalar
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Eur J Radiol
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To investigate whether there are metabolite changes in basal ganglia of children with complete healing of rheumatic fever (RF),
history of Syndenham chorea (SC) and obsessive compulsive-tic disorder (OCTD) developed after RF when compared with healthy controls
and each other. Material and methods: A total of 49 children with history of RF and 31 healthy controls were included into the study. All
patients and control group underwent a detailed neuropsychiatric evaluation. Children with the history of RF were classified into three groups
as; group 1: with history of RF without neuropsychiatric complications (NCRF), group 2: only with history of SC (HSC), group 3: with HSC
and OCTD (OCTD). After MR imaging, single voxel MR spectroscopy was performed in all subjects. Voxels (15 × 15 × 15 mm) were placed
in basal ganglia. N-acetyl aspartate (NAA)/creatin (Cr), and choline (Cho)/Cr ratios were calculated. Results: OCTD were detected in 13
children with HSC. NAA/Cr ratio was found to be decreased in these children when compared with NCRF (n:29), HSC without OCTD (n:7)
and control groups (n:31). No significant difference was found in metabolite ratios of children with HSC without OCTD when compared with
NCRF and control groups. There were no significant differences in Cho/Cr ratio between patient and control groups. Conclusion: Although
MR imaging findings was normal, MR spectroscopy findings (decreased NAA/Cr ratio) in our study support the neuronal loss in basal ganglia
of children with OCTD and could indicate the development of permanent damage.
Açıklama
Anahtar Kelimeler
Rheumatic fever, Chorea, Obsessive compulsive disorder, Magnetic resonance spectroscopy
Kaynak
Eur J Radiol
WoS Q Değeri
Scopus Q Değeri
Cilt
49
Sayı
Künye
Alkan, A. Kutlu, R. Koçak, G. Sığırcı, A. Emul, M. Doğan, S. Aslan, M. Saraç, K. Yakıncı, M. C. (2004). Brain MR spectroscopy in children with a history of rheumatic fever with a special emphasis on neuropsychiatric complications. Eur J Radiol. 49; 224-228.
