(E)-1-(4-Hydroxyphenyl)-3-(substituted-phenyl) prop-2-en-1-ones: Synthesis, In Vitro Cytotoxic Activity and Molecular Docking Studies

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dc.authoridGORGULU, AHMET/0000-0002-7549-1524
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridBahar, Mehmet Refik/0000-0002-7922-3850
dc.authoridKORAN, KENAN/0000-0002-2218-7211
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridUSLU, HARUN/0000-0001-8827-8557
dc.authoridGorgulu, Ahmet Orhan/0000-0003-0632-4834
dc.authorwosidGORGULU, AHMET/KBA-2787-2024
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidBahar, Mehmet Refik/ABI-6343-2020
dc.authorwosidKORAN, KENAN/L-6764-2016
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidUSLU, HARUN/P-3681-2019
dc.authorwosidÇALIŞKAN, ERAY/W-6973-2018
dc.contributor.authorSirka, Lutfiye
dc.contributor.authorDogan, Hacer
dc.contributor.authorBahar, Mehmet Refik
dc.contributor.authorCaliskan, Eray
dc.contributor.authorTekin, Suat
dc.contributor.authorUslu, Harun
dc.contributor.authorKoran, Kenan
dc.date.accessioned2024-08-04T20:56:14Z
dc.date.available2024-08-04T20:56:14Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of chalcone compounds (2-11) were designed and synthesized to determine their cytotoxic effects. The structures of 2-11 were fully characterized by their physical and spectral data. The in vitro cytotoxic effects of 2-11 were evaluated against human ovarian cancer (A2780), breast cancer (MCF-7) and prostate cancer (PC-3 and LNCaP) cell lines. The activity potentials of compounds were further evaluated through molecular docking studies with AutoDock4 and Vina softwares. All the compounds (except compound 5) showed significant cytotoxic effects at high doses in all cancer cell lines. Among all the compounds studied, one compound i.e. compound 2 demonstrated dose-dependent activity, particularly against A2780/LNCaP cancer cell lines. The most effective compounds 8, 9, 10 and 11 reduced the cell viability of A2780, MCF-7, PC-3 and LNCaP cells by 50-98%, while other compounds 2, 4 and 7 reduced the cell viability of A2780 cells by 70-90% at concentrations of 50 and 100 mu M.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [116Z758]en_US
dc.description.sponsorshipThe researchers are grateful to The Scientific and Technological Research Council of Turkey for financial support of this work (Project no: 116Z758).en_US
dc.identifier.doi10.17344/acsi.2021.7080
dc.identifier.endpage292en_US
dc.identifier.issn1318-0207
dc.identifier.issn1580-3155
dc.identifier.issue2en_US
dc.identifier.pmid35861092en_US
dc.identifier.startpage281en_US
dc.identifier.urihttps://doi.org/10.17344/acsi.2021.7080
dc.identifier.urihttps://hdl.handle.net/11616/102150
dc.identifier.volume69en_US
dc.identifier.wosWOS:000883415800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSlovensko Kemijsko Drustvoen_US
dc.relation.ispartofActa Chimica Slovenicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChalconeen_US
dc.subjectcytotoxicen_US
dc.subjectA2780en_US
dc.subjectMTT assayen_US
dc.subjectmolecular dockingen_US
dc.title(E)-1-(4-Hydroxyphenyl)-3-(substituted-phenyl) prop-2-en-1-ones: Synthesis, In Vitro Cytotoxic Activity and Molecular Docking Studiesen_US
dc.typeArticleen_US

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