Association between latent toxoplasmosis and clinical course of schizophrenia - continuous course of the disease is characteristic for Toxoplasma gondii-infected patients

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dc.authoridkartalcı, şükrü/0000-0003-2560-0355
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridUnal, Suheyla/0000-0003-3266-6256
dc.authoridUnal, Suheyla/0000-0003-3266-6256;
dc.authorwosidkartalcı, şükrü/ABI-1106-2020
dc.authorwosidAkarsu, Gulay Aral/AAP-8001-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidUnal, Suheyla/AAS-2388-2020
dc.authorwosidUnal, Suheyla/HJH-7559-2023
dc.authorwosidUnal, Suheyla/JVO-8367-2024
dc.authorwosidCELIK, Tuncay/KXQ-9904-2024
dc.contributor.authorCelik, Tuncay
dc.contributor.authorKartalci, Sukru
dc.contributor.authorAytas, Ozgur
dc.contributor.authorAkarsu, Gulay Aral
dc.contributor.authorGozukara, Harika
dc.contributor.authorUnal, Suheyla
dc.date.accessioned2024-08-04T20:57:12Z
dc.date.available2024-08-04T20:57:12Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the association between various clinical aspects of schizophrenia and seropositivity against Toxoplasma gondii (Nicolle et Manceaux, 1908). We selected 94 patients with schizophrenia and investigated the seropositivity rate for anti-T. gondii IgG antibodies by ELISA. Clinical parameters of schizophrenic patients such as illness type and status, clinical course, awareness of the illness and need for electroconvulsive therapy (ECT) were compared with their serological status. Anti-T. gondii IgG antibodies were detected in 43 (46%) of schizophrenic patients. Chronic patients had a rate of 34 (72%) seropositivity, whereas 9 (22%) of the patients with partial remission showed evidence of latent toxoplasmosis. Of continuous patients, 35 (81%) were found to be seropositive and this rate was significantly more than in the other groups. The rate of latent toxoplasmosis was detected significantly higher in patients who lack awareness of schizophrenia (36, i.e. 72%) than the patients who were aware of their illnesses (7, i.e. 16%). Anti-T. gondii IgG antibodies were detected in 38 (70%) of ECT performed patients while this percentage was 13% in the ones who had never been treated with ECT. This difference was also statistically significant. We showed that Toxoplasma-infected subjects had 15x higher probability of having continuous course of disease than Toxoplasma-free subjects. Our results put forth the possibility of latent toxoplasmosis to have a negative impact on the course of schizophrenia and treatment response of schizophrenic patients.en_US
dc.identifier.issn0015-5683
dc.identifier.issn1803-6465
dc.identifier.urihttps://hdl.handle.net/11616/102429
dc.identifier.volume62en_US
dc.identifier.wosWOS:000364829500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherFolia Parasitologicaen_US
dc.relation.ispartofFolia Parasitologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttoxoplasmosisen_US
dc.subjectschizophrenia patientsen_US
dc.subjectprognosisen_US
dc.subjectserologyen_US
dc.titleAssociation between latent toxoplasmosis and clinical course of schizophrenia - continuous course of the disease is characteristic for Toxoplasma gondii-infected patientsen_US
dc.typeArticleen_US

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