Clinical and Imaging Findings in Childhood Posterior Reversible Encephalopathy Syndrome

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dc.authoridKılıç, Betül/0000-0003-0884-2635
dc.authoridSigirci, Ahmet/0000-0001-9221-0002
dc.authorwosidTabel, Yilmaz/AAF-9801-2020
dc.authorwosidKılıç, Betül/ABS-2287-2022
dc.authorwosidSigirci, Ahmet/ABG-7387-2020
dc.contributor.authorGungor, Serdal
dc.contributor.authorKilic, Betul
dc.contributor.authorTabel, Yilmaz
dc.contributor.authorSelimoglu, Ayse
dc.contributor.authorOzgen, Unsal
dc.contributor.authorYilmaz, Sezai
dc.contributor.authorSigirci, Ahmet
dc.date.accessioned2024-08-04T20:57:26Z
dc.date.available2024-08-04T20:57:26Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective Posterior reversible encephalopathy syndrome (PRES) is characterized by typical radiologic findings in the posterior regions of the cerebral hemispheres and cerebellum. The symptoms include headache, nausea, vomiting, visual disturbances, focal neurologic deficits, and seizures. The aim of this study is to evaluate the clinical and radiological features of PRES in children and to emphasize the recognition of atypical features. Materials & Methods We retrospectively examined 23 children with PRES from Mar 2010-Apr 2015 in Inonu University Turgut Ozal Medical Center in Turkey. We compared the clinical features and cranial MRI findings between underlying diseases of PRES. Results The most common precipitating factors were hypertension (78.2%) and medications, namely immunosuppressive and antineoplastic agents (60.8%). Manifestations included mental changes (100%), seizures (95.6%), headache (60.8%), and visual disturbances (21.7%) of mean 3.6 (range 1-10) days' duration. Cranial magnetic resonance imaging (MRI) showed bilateral occipital lesions in all patients, associated in 82.6% with less typical distribution of lesions in frontal, temporal or parietal lobes, cerebellum, corpus callosum, basal ganglia, thalamus, and brain stem. Frontal involvement was predominant, observed in 56.5% of patients. Clinical recovery was followed by radiologic resolution in all patients. Conclusion PRES is often unsuspected by the clinician, thus radiologists may be the first to suggest this diagnosis on an MRI obtained for seizures or encephalopathy. Atypical MRI finding is seen quite often. Rapid diagnosis and treatment are required to avoid a devastating outcome.en_US
dc.identifier.endpage25en_US
dc.identifier.issn1735-4668
dc.identifier.issn2008-0700
dc.identifier.issue1en_US
dc.identifier.pmid29379559en_US
dc.identifier.startpage16en_US
dc.identifier.urihttps://hdl.handle.net/11616/102597
dc.identifier.volume12en_US
dc.identifier.wosWOS:000429622200002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIranian Child Neurology Socen_US
dc.relation.ispartofIranian Journal of Child Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectPosterior reversible encephalopathy syndromeen_US
dc.subjectSeizureen_US
dc.subjectAtypical radiological findingen_US
dc.titleClinical and Imaging Findings in Childhood Posterior Reversible Encephalopathy Syndromeen_US
dc.typeArticleen_US

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