Prevalence of type 2 diabetes mellitus, metabolic syndrome, and related morbidities in overweight and obese children

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dc.authoridDundar, Ismail/0000-0003-1468-6405
dc.authoridDundar, Ismail/0000-0003-1468-6405
dc.authorwosidDundar, Ismail/ABG-2027-2021
dc.authorwosidDundar, Ismail/AAA-2528-2021
dc.contributor.authorDundar, Ismail
dc.contributor.authorAkinci, Aysehan
dc.date.accessioned2024-08-04T21:00:54Z
dc.date.available2024-08-04T21:00:54Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives The aim of the study was to determine the prevalence of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and other comorbidities in overweight and obese children in Malatya, Turkey. Methods Retrospective cross-sectional study. We studied 860 obese and overweight children and adolescents (obese children Body mass index (BMI) >95th percentile, overweight children BMI >85th percentile) aged between 6 and 18 years. The diagnosis of MetS, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and T2DM were defined according to modified the World Health Organization criteria adapted for children. Other comorbidities were studied. Results Subjects (n=860) consisted of 113 overweight and 747 obese children of whom 434 (50.5%) were girls. MetS was significantly more prevalent in obese than overweight children (43.8 vs. 2.7%, p<0.001), and in pubertal than prepubertal children (41.1 vs. 31.7%, p<0.001). Mean homeostasis model assessment for insulin ratio (HOMA-IR) was 3.6 +/- 2.0 in the prepubertal and 4.9 +/- 2.4 in pubertal children (p<0.001). All cases underwent oral glucose tolerance test and IGT, IFG, and T2DM were diagnosed in 124 (14.4%), 19 (2.2%), and 32 (3.7%) cases, respectively. Insulin resistance (IR) was present in 606 cases (70.5%). Conclusions Puberty and obesity are important risk factors for MetS, T2DM, and IR. The prevalence of MetS, T2DM, and other morbidities was high in the study cohort. Obese children and adolescents should be carefully screened for T2DM, insulin resistance, hyperinsulinism, dyslipidemia, hypertension, IGT, and IFG. The prevention, early recognition, and treatment of obesity are essential to avoid associated morbidities.en_US
dc.identifier.doi10.1515/jpem-2021-0271
dc.identifier.endpage441en_US
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue4en_US
dc.identifier.pmid35026882en_US
dc.identifier.startpage435en_US
dc.identifier.urihttps://doi.org/10.1515/jpem-2021-0271
dc.identifier.urihttps://hdl.handle.net/11616/103906
dc.identifier.volume35en_US
dc.identifier.wosWOS:000742317700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildhood obesityen_US
dc.subjectinsulin resistanceen_US
dc.subjectmetabolic syndromeen_US
dc.subjecttype 2 diabetes mellitusen_US
dc.titlePrevalence of type 2 diabetes mellitus, metabolic syndrome, and related morbidities in overweight and obese childrenen_US
dc.typeArticleen_US

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