Evaluation of CSF flow dynamics in patients with schizophrenia using phase-contrast cine MRI

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dc.authoridkartalcı, şükrü/0000-0003-2560-0355
dc.authoridKahraman, Aysegul Sagir/0000-0002-2147-1181
dc.authorwosidkartalcı, şükrü/ABI-1106-2020
dc.authorwosidKahraman, Aysegul Sagir/S-1526-2016
dc.contributor.authorKartalci, Sukru
dc.contributor.authorErbay, Mehmet Fatih
dc.contributor.authorKahraman, Aysegul
dc.contributor.authorcandir, Fatih
dc.contributor.authorErbay, Lale Gonenir
dc.date.accessioned2024-08-04T20:58:44Z
dc.date.available2024-08-04T20:58:44Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPatients with schizophrenia show progressive clinical deterioration. Brain abnormalities have been suggested in these patients, including enlargement of the lateral ventricles, increased cerebrospinal fluid (CSF) volume and reductions in the frontal and temporal lobes. CSF flow pathology is a central factor in the development of many neurological disorders, but much less is known about the role of CSF flow dynamics in schizophrenia. In this study, parameters of CSF flow dynamics at the aqueduct level of 50 schizophrenic patients were compared to those of 50 controls using phase-contrast cine magnetic resonance imaging. Patients had lower peak velocity, lower net forward volume, and lower average flow over the range studied than controls. The average velocity was significantly lower in patients exhibiting violent behavior compared to non-violent patients. The aqueduct tendedto be larger in schizophrenic patients with earlier age of onset of the disorder. Furthermore, as the number of hospitalizations increased, the average velocity and flow over the range studied decreased commensurately. This study demonstrated that CSF flow dynamics are altered in patients with schizophrenia. The results indicated that additional studies of CSF flow dynamics in schizophrenia are needed, along with volumetric examinations of the brain, to elucidate the pathophysiology of the disease.en_US
dc.identifier.doi10.1016/j.psychres.2021.114172
dc.identifier.issn0165-1781
dc.identifier.issn1872-7123
dc.identifier.pmid34407492en_US
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2021.114172
dc.identifier.urihttps://hdl.handle.net/11616/103106
dc.identifier.volume304en_US
dc.identifier.wosWOS:000697945200003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSchizophreniaen_US
dc.subjectCSF flowen_US
dc.subjectPhase-contrast cine magnetic resonanceen_US
dc.subjectimaging (PC-MRI)en_US
dc.titleEvaluation of CSF flow dynamics in patients with schizophrenia using phase-contrast cine MRIen_US
dc.typeArticleen_US

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