EFFICACY OF HIGH-DOSE AMINO-ACID SOLUTION ON SPINAL-CORD INJURY-INDUCED BY FOCAL ND-YAG LASER IRRADIATION

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dc.contributor.authorCOLAK, A
dc.contributor.authorNURLU, G
dc.contributor.authorACIKGOZ, B
dc.contributor.authorOZCAN, OE
dc.date.accessioned2024-08-04T20:58:37Z
dc.date.available2024-08-04T20:58:37Z
dc.date.issued1995
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this experimental study, a neodymium: yttrium-aluminium-garnet (Nd:YAG) laser was used to induce highly reproducible focal spinal cord lesions in anaesthetized guinea pigs. The efficacy of high dose amino acid solution (HDAAS) on this injury is investigated. Experiments were performed on 36 animals divided into three groups; sham operated controls, laser irradiated surgical controls, and amino acid groups. Acute responses to injury were evaluated with somatosensory (SSEP) and motor evoked potentials (MEP) and functional recovery was assessed for 8 weeks using the inclined plane technique. In the laser irradiated surgical control group, MEP disappeared one hour after the laser injury, but SSEP revealed changes of amplitude and latency. In this group, the average value of the inclined plane at 24 hours after the laser application was 45.3 +/- 1.4 degrees. In the amino acid group, at the sixth hour of injury, MEP and SSEP changes improved with infusion of HDAAS for 4 hours. This improvement was statistically significant (for latency of SSEP U = 140 p < 0.05). Inclined plane value at 24 hours after the laser application was 65.5 +/- 1.2 degrees in this group. This study showed that application of Nd:YAG laser irradiation on the spinal cord induced spinal cord injury which presented as paraparesis, HDAAS may provide significant therapeutic protection in secondary damage following this injury and may have a potential role in the treatment of acute spinal cord injury.en_US
dc.identifier.doi10.1007/BF01404952
dc.identifier.endpage79en_US
dc.identifier.issn0001-6268
dc.identifier.issn0942-0940
dc.identifier.issue1-2en_US
dc.identifier.pmid8561042en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.1007/BF01404952
dc.identifier.urihttps://hdl.handle.net/11616/103016
dc.identifier.volume133en_US
dc.identifier.wosWOS:A1995QN03400015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofActa Neurochirurgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBRANCHED CHAIN AMINO ACID SOLUTIONen_US
dc.subjectMOTOR EVOKED POTENTIALen_US
dc.subjectND-YAG LASERen_US
dc.subjectSOMATOSENSORY EVOKED POTENTIALen_US
dc.subjectSPINAL CORD INJURYen_US
dc.titleEFFICACY OF HIGH-DOSE AMINO-ACID SOLUTION ON SPINAL-CORD INJURY-INDUCED BY FOCAL ND-YAG LASER IRRADIATIONen_US
dc.typeArticleen_US

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