Evaluation of proliferative-apoptotic activity in inactive, proliferative, hyperplastic endometria and endometrioid carcinomas

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dc.authoridAYDIN, Nasuhi/0000-0003-3145-2432
dc.authorwosidAydin, Nasuhi E/B-6536-2012
dc.authorwosidAYDIN, Nasuhi Engin/L-1607-2019
dc.authorwosidAYDIN, Nasuhi/O-9043-2016
dc.contributor.authorUsta, Ufuk
dc.contributor.authorEdali, Mehmet Naci
dc.contributor.authorAydin, Nasuhi Engin
dc.date.accessioned2024-08-04T20:58:45Z
dc.date.available2024-08-04T20:58:45Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: The role of proliferative and apoptotic mechanisms in various endometrial pathologies and in proliferative and atrophic endometria was assessed by immunohistochemical methods. Patients and Methods: A total of 55 cases consisting of 13 endometrioid carcinomas, eight cases of endometrial hyperplasia, 15 cases of disordered proliferation, 12 cases with proliferative and seven with inactive/athrophic endometria gathered from the local archives were included in the study. Immunohistochernical markers and stains, namely bcl-2, an antiapopitotic marker, and Ki-67, a proliferative marker were applied to the sections of selected diagnostic tissue blocks. Additionally, mitotic counts per 10 high power fields were obtained in cases of hyperplasia and carcinoma. Results: Mean H-score value for bcl-2 reaction was 0.48 for endometrioid carcinoma. Mean H-score values for cases of hyperplasia, disordered proliferation, proliferation and atrophy were calculated as 1.93, 1.62, 1.5 and 1.0, respectively. Ki-67 proliferation index for endometrioid carcinoma was 48.9%. This index was 32%, 29%, 31.5% and 8.4% for hyperplasia, disordered proliferation, proliferation and atrophy, respectively. Conclusion: Staining with bcl-2 peaked in cases of hyperplasia, and lost its intensity as nuclear atypia became evident. Weakest staining was observed in cases with grade II and III endometrioid carcinomas. In contrast, proliferative indexes increased with increasing, grades of carcinoma.en_US
dc.identifier.endpage35en_US
dc.identifier.issn1301-3149
dc.identifier.issue1en_US
dc.identifier.startpage28en_US
dc.identifier.urihttps://hdl.handle.net/11616/103132
dc.identifier.volume24en_US
dc.identifier.wosWOS:000257598600007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAves Yayincilik, Ibrahim Karaen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcarcinoma endometrioiden_US
dc.subjectendometrial hyperplasiaen_US
dc.subjectgenes bcl-2en_US
dc.subjectKi-67 antigenen_US
dc.titleEvaluation of proliferative-apoptotic activity in inactive, proliferative, hyperplastic endometria and endometrioid carcinomasen_US
dc.typeArticleen_US

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