Oxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic State

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dc.authoridbalci ozyurt, aylin/0000-0002-0060-271X
dc.authoridSağaltıcı, Eser/0000-0002-4217-2658
dc.authorwosidbalci ozyurt, aylin/HKE-3259-2023
dc.authorwosidSağaltıcı, Eser/AAT-3056-2020
dc.contributor.authorErmis, Berna
dc.contributor.authorSagaltici, Eser
dc.contributor.authorUnal, Ahmet
dc.contributor.authorAlici, Demet
dc.contributor.authorOzyurt, Ayse Binnur
dc.date.accessioned2024-08-04T21:00:08Z
dc.date.available2024-08-04T21:00:08Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This study aimed to investigate oxidative metabolism and oxidative DNA damage in the state of euthymic and active disease in patients with Bipolar disorder (BD). Methods: 40 active (26 mania and14 depression episodes) and 40 euthymic state of disease of the 80 patients with BD and 48 healthy volunteers were included to the study. Measurement of the levels of serum total antioxidant (TAS) and serum total oxidant (TOS), Oxidative Stress Index (OSI), and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels were calculated and evaluated. Hamilton Depression Rating Scale (HAM-D), Young Mania Rating Scale (YMRS) and Clinical Global Impression Scale (CGI) were administered. Results: In patients with BD, TAS, TOS, OSI, and 8-OHdG levels were significantly higher than controls (all p<0.001). TOS level significantly higher in female than men in BD (p=0.016). A significantly positive weak correlation was detected between the TAS level and CGI score (p=0.031, r=0.241), HAM-D score (p=0.040, r=0.231) in BD. When patients in the active and euthymic state were compared with the control group separately, in both groups TAS, TOS, OSI, and 8-OHdG levels were significantly higher than controls (all p<0.001). However, there was no significant difference in TOS, OSI, and 8-OHdG levels between patients in the active or euthymic state of disease. Conclusion: Oxidants and DNA damage are high in patient with BD. No difference of the oxidants and DNA damage between the active and euthymic state of disease reveals that oxidative stress damages on the body although the symptoms of the disease to quiet down.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of University of Gaziantep [TF.12.05/2013]en_US
dc.description.sponsorshipFunding for this study was provided by a grant from the Scientific Research Project Coordination Unit of University of Gaziantep (TF.12.05/2013).en_US
dc.identifier.doi10.5455/PBS.20210610075010
dc.identifier.endpage257en_US
dc.identifier.issn2636-834X
dc.identifier.issue4en_US
dc.identifier.startpage249en_US
dc.identifier.urihttps://doi.org/10.5455/PBS.20210610075010
dc.identifier.urihttps://hdl.handle.net/11616/103822
dc.identifier.volume11en_US
dc.identifier.wosWOS:000737456900004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherYerkure Tanitim & Yayincilik Hizmetleri A Sen_US
dc.relation.ispartofPsychiatry and Behavioral Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative Stressen_US
dc.subjectLevel of Total Antioxidanten_US
dc.subjectLevel of Total Oxidanten_US
dc.subjectOxidative DNA Damageen_US
dc.subject8-hydroxydeoxyguanosineen_US
dc.subjectBipolar Disorderen_US
dc.titleOxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic Stateen_US
dc.typeArticleen_US

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