Effects of Nigella sativa oil on rat liver development

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dc.authoridYÜNCÜ, MEHMET/0000-0002-2519-6834;
dc.authorwosidYÜNCÜ, MEHMET/AAG-9317-2020
dc.authorwosidSari, İbrahim/A-5771-2018
dc.contributor.authorYuncu, Mehmet
dc.contributor.authorSahin, Mehmet
dc.contributor.authorBayat, Nuray
dc.contributor.authorSari, Ibrahim
dc.date.accessioned2024-08-04T20:58:33Z
dc.date.available2024-08-04T20:58:33Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNigella sativa and its oil are frequently consumed among the people. However, its toxic effect on fetus is not known when used during pregnancy. In this study, we aimed to investigate the effect of Nigella sativa oil on the liver development of rat fetus. Ten female rats were used in this study, four of them consist of control group and six of them composed of the experimental group. When the pregnancy was started, 2.5 ml/kg/day saline or 2.5 ml/kg/day Nigella sativa oil were administered by oral orogastric route for control and experimental groups, respectively. After deliveries, newborn rats were weighed and sacrificed by cervical dislocation. Livers, obtained from newborn rats, were fixed with formalin and embedded with paraffin wax to prepare blocks. Sections obtained from liver blocks were stained with hematoxylin-eosin and Masson trichrome, and examined by light microscope. There were no statistically significant differences between groups in histopathological findings of liver tissues of newborns, except hydrophic degeneration, when the groups were compared. In conclusion, using Nigella sativa oil during pregnancy do not produce toxic effects on fetus liver.en_US
dc.identifier.doi10.5455/GMJ-30-2013-162
dc.identifier.endpage184en_US
dc.identifier.issn2564-7784
dc.identifier.issn2564-7040
dc.identifier.issue3en_US
dc.identifier.startpage180en_US
dc.identifier.urihttps://doi.org/10.5455/GMJ-30-2013-162
dc.identifier.urihttps://hdl.handle.net/11616/102973
dc.identifier.volume19en_US
dc.identifier.wosWOS:000439219900009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAves Press Ltden_US
dc.relation.ispartofEuropean Journal of Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNigella sativa oilen_US
dc.subjectliveren_US
dc.subjectraten_US
dc.subjectnewbornen_US
dc.titleEffects of Nigella sativa oil on rat liver developmenten_US
dc.typeArticleen_US

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