Beijing W and major spoligotype families of mycobacterium tuberculosis strains isolated from tuberculosis patients in eastern Turkey
Yükleniyor...
Dosyalar
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
New Microbiologica
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this study was to determine the Beijing/W family and major phylogenetic clades of Mycobacterium tuberculosis
strains of tuberculosis patients in a city with a tuberculosis incidence higher than the country average. A
total of 220 M. tuberculosis strains isolated over a period of more than four years were typed by spoligotyping.
Spoligotyping resulted in 64 different patterns, 38 (17.3%) of which were unique, and 26 were clusters including 182
(82.7%) strains. The major shared types were ST 53 (n=55, 25%), ST 41 (LAM7-TUR; n=19, 8.6%), and ST 284 (n=15,
6.8%). The major clades observed ranked in the following order: ill-defined T superfamily (n=112, 50.9%); LatinoAmerican-Mediterranean
(LAM; n=33, 15%); Haarlem (n=24, 10.9%); and the S family (n=9, 4.1%). Three strains were
in the Beijing family. A high number of strains (33 strains) showed patterns that did not fall within any of the major
clades described. M. tuberculosis strains in Malatya have both STs showing a widespread distribution over the
world and those restricted to this city, confirming the highly diverse nature of tuberculosis. Our results suggest that
the Beijing clade, which is more prevalent among the strains with MDR and isoniazid resistance, is currently not a
problem in Eastern Turkey.
Açıklama
Anahtar Kelimeler
Tuberculosis, Turkey, Molecular epidemiology, Spoligotyping, Beijing genotype
Kaynak
New Microbiologica
WoS Q Değeri
Scopus Q Değeri
Cilt
32
Sayı
3
Künye
Otlu, B. Durmaz, R. Günal, S. Sola, C. Zozio, T. Rastogi, N. (2009). Beijing W and major spoligotype families of mycobacterium tuberculosis strains isolated from tuberculosis patients in eastern Turkey. New Microbiologica. 32(3), 255–263.
