Impaired coronary blood flow in patients with metabolic syndrome: Documented by Thrombolysis in Myocardial Infarction (TIMI) frame count method

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dc.authoridBicer, Asuman/0000-0001-7766-9560
dc.authorwosidBicer, Asuman/ABF-3339-2020
dc.contributor.authorTurhan, H
dc.contributor.authorErbay, AR
dc.contributor.authorYasar, AS
dc.contributor.authorBicer, A
dc.contributor.authorSasmaz, H
dc.contributor.authorYetkin, E
dc.date.accessioned2024-08-04T20:59:00Z
dc.date.available2024-08-04T20:59:00Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Endothelium plays an important role in regulating coronary vascular tone. In addition, several of cardiovascular risk factors that are associated metabolic syndrome have been reported to be associated with endothelial dysfunction. In the present study we aimed to evaluate the coronary blood flow in patients with metabolic syndrome by means of the Thrombolysis in Myocardial Infarction (TIMI) frame count. Method Forty-two patients with metabolic syndrome (group 1) and 42 control subjects without metabolic syndrome (group II) were included in the study. All subjects had angiographically proven normal coronary arteries. Diagnosis of metabolic syndrome was based on the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines published in 2001. Coronary flow rates of all subjects were documented by TIMI frame count method. Results TIMI frame counts for each of the major epicardial coronary arteries were found to be significantly higher in patients with metabolic syndrome compared with control subjects (corrected TIMI frame count for left anterior descending coronary artery: 35 +/- 7 vs 25 +/- 7, respectively; left circumflex coronary artery: 32 9 vs 25 7, respectively; right coronary artery: 31 +/- 9 vs 24 +/- 5, respectively; P <.001 for all). Statistically significant independent relationships were found between TIMI frame count and body mass index (R-2 = 0.480, P =.009), waist circumference (R-2 = 0.551, P = .001), and triglyceride level (R-2 = 0.434, P =.036). Conclusion We have shown for the first time that patients with metabolic syndrome and angiographically normal coronary arteries have higher TIMI frame counts for all 3 coronary vessels, indicating impaired coronary blood flow, compared to control subjects without metabolic syndrome.en_US
dc.identifier.doi10.1016/j.ahj.2004.05.016
dc.identifier.endpage794en_US
dc.identifier.issn0002-8703
dc.identifier.issn1097-5330
dc.identifier.issue5en_US
dc.identifier.pmid15523308en_US
dc.identifier.startpage789en_US
dc.identifier.urihttps://doi.org/10.1016/j.ahj.2004.05.016
dc.identifier.urihttps://hdl.handle.net/11616/103367
dc.identifier.volume148en_US
dc.identifier.wosWOS:000225045100008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofAmerican Heart Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBody-Fat Distributionen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectNitric-Oxideen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectHearten_US
dc.subjectArteryen_US
dc.subjectAtherosclerosisen_US
dc.subjectContractionen_US
dc.subjectRelaxationen_US
dc.subjectMechanismsen_US
dc.titleImpaired coronary blood flow in patients with metabolic syndrome: Documented by Thrombolysis in Myocardial Infarction (TIMI) frame count methoden_US
dc.typeArticleen_US

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