A Novel Approach for Preventing Biofilm Formation on Various Breast Implant Surfaces: Bacteriophage Therapy

Basit Öğe Kaydı
dc.contributor.authorKarasu, Oguzhan
dc.contributor.authorAyhan, M. Suhan
dc.contributor.authorDuran, Muzaffer
dc.contributor.authorSahin, Elif Ayca
dc.contributor.authorAyaz, Naim Deniz
dc.contributor.authorYalinay, A. Meltem
dc.date.accessioned2026-04-04T13:33:25Z
dc.date.available2026-04-04T13:33:25Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: Capsular contracture is a common complication in breast implant surgery, with subclinical bacterial inflammation being a significant factor. Traditional methods to prevent capsular contracture include antibiotic irrigation and systemic antibiotics. However, the rise of antibiotic-resistant bacteria has driven the need for alternative treatments. Bacteriophages, capable of lysing bacteria and preventing biofilm formation, are emerging as a potential alternative. This study aimed to compare the efficacy of local bacteriophage therapy and local antibiotic treatment in preventing biofilm formation on breast implants. Methods: Fifty-four Wistar Albino rats were divided into 3 groups: control, antibiotic, and bacteriophage, each with 3 subgroups for different time points (6 hours, 24 hours, and 30 days). Three types of implant surfaces (smooth, textured, and polyurethane) were incubated with a biofilm-producing strain of Staphylococcus epidermidis before implantation. The implant surfaces in the experimental groups were treated with either antibiotic or bacteriophage solutions before implantation. Samples were collected at 6 hours, 24 hours, and 30 days after implantation for colony counting and mRNA analysis of the sesI gene. Results: Both bacteriophage and antibiotic treatments significantly reduced colony counts and mRNA expression compared with the control group at all time points (P < 0.05). No significant difference was found between the antibiotic and bacteriophage groups. Textured and polyurethane implants showed lower bacterial loads in the experimental groups compared with smooth implants. Conclusion: This study highlights bacteriophages as a promising alternative to antibiotics for preventing biofilm formation on breast implants, representing a pioneering effort in demonstrating their potential.
dc.description.sponsorshipGazi University Scientific Research Projects Unit [TTU-2022-8269]
dc.description.sponsorshipThis study was supported by a grant from the Gazi University Scientific Research Projects Unit (project no. TTU-2022-8269).
dc.identifier.doi10.1097/PRS.0000000000012132
dc.identifier.endpage761
dc.identifier.issn0032-1052
dc.identifier.issn1529-4242
dc.identifier.issue5
dc.identifier.orcid0000-0002-2215-2756
dc.identifier.pmid40178584
dc.identifier.startpage751
dc.identifier.urihttps://doi.org/10.1097/PRS.0000000000012132
dc.identifier.urihttps://hdl.handle.net/11616/109149
dc.identifier.volume156
dc.identifier.wosWOS:001603862400002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofPlastic and Reconstructive Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectCapsular Contracture
dc.subjectInfected Wounds
dc.subjectAssociation
dc.subjectAntagonists
dc.subjectProsthesis
dc.subjectResistance
dc.subjectSurgery
dc.titleA Novel Approach for Preventing Biofilm Formation on Various Breast Implant Surfaces: Bacteriophage Therapy
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu