Comparison of the chemopreventive potentials of melatonin and vitamin E plus selenium on 7,12-dimethylbenz[a]anthracene-induced inhibition of mouse liver antioxidant enzymes

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dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authoridGenç, Metin Fikret/0000-0002-6244-0517
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.authorwosid/ABG-9766-2020
dc.authorwosidGenç, Metin Fikret/ABI-2169-2020
dc.contributor.authorBatcioglu, K
dc.contributor.authorKaragözler, AA
dc.contributor.authorGenç, M
dc.contributor.authorÇelik, S
dc.date.accessioned2024-08-04T20:57:29Z
dc.date.available2024-08-04T20:57:29Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractChemoprevention is a rapidly growing area of oncology that is identifying agents with a potentially preventive role in cancer. In this study, it was our goal to compare the chemopreventive effects of vitamin E plus selenium, and melatonin. Forty female mice were divided into four equal groups. The first group served as control. The second group had i.p. injections of 7,12-dimethylbenz[a]anthracene (DMBA) (20 mg/kg body weight) in corn oil for 21 days. The third group had the same procedure of DMBA injections as the second group and received vitamin E + selenium (90 mug + 1.8 mug/day), simultaneously. The fourth group had DMBA injections and melatonin (4.2 mg/kg body weight), simultaneously. DMBA alone caused significant inhibition of hepatic glutathione peroxidase (GSHPx), catalase (CAT), and superoxide dismutase (SOD) in the second group. In the third group, vitamin E + selenium restored DMBA-induced GSHPx inhibition significantly whereas CAT and SOD inhibition remained essentially unchanged. In the fourth group, melatonin not only significantly decreased DMBA-induced GSHPx inhibition but also fully reversed CAT and SOD inhibitions caused by DMBA. We speculate that melatonin alone provides better chemoprevention against DMBA-induced oxidative stress than the vitamin E + selenium combination. (C) 2002 Lippincott Williams Wilkins.en_US
dc.identifier.doi10.1097/00008469-200202000-00008
dc.identifier.endpage61en_US
dc.identifier.issn0959-8278
dc.identifier.issn1473-5709
dc.identifier.issue1en_US
dc.identifier.pmid11917209en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.1097/00008469-200202000-00008
dc.identifier.urihttps://hdl.handle.net/11616/102671
dc.identifier.volume11en_US
dc.identifier.wosWOS:000174066300008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchemopreventionen_US
dc.subjectDMBAen_US
dc.subjectmelatoninen_US
dc.subjectseleniumen_US
dc.subjectvitamin Een_US
dc.titleComparison of the chemopreventive potentials of melatonin and vitamin E plus selenium on 7,12-dimethylbenz[a]anthracene-induced inhibition of mouse liver antioxidant enzymesen_US
dc.typeArticleen_US

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