Effect of peritonitis on gallbladder smooth muscle contractility in guinea pigs

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dc.authorid113496en_US
dc.contributor.authorTemiz Kaya, Tijen
dc.contributor.authorKöylüoğlu, Gökhan
dc.contributor.authorKaradaş, Barış
dc.contributor.authorTuran, Yıldız
dc.contributor.authorBağcıvan, İhsan
dc.contributor.authorCeran Özcan, Canan
dc.contributor.authorGökgöz, Mustafa Şehsuvar
dc.date.accessioned2017-08-16T06:22:47Z
dc.date.available2017-08-16T06:22:47Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. The mechanisms involved in the impaired gallbladder contractile response in peritonitis are unknown. The aim of this study was to determine the effect of peritonitis on the contraction and relaxation responses to different agonists in gallbladder smooth muscle in guinea pig. Materials and methods. Peritonitis was induced by cecal ligation and puncture (CLP) in 10 guinea pigs. Another group of 10 guinea pigs underwent a sham operation and acted as controls. Twenty-four hours after the operation, the guinea pigs were killed, and gallbladder strips were placed in organ bath. The contraction responses to KCl, carbachol, and histamine, and relaxation responses to cyclooxygenase inhibitors (indomethacin, nimesulide, and DFU) on KCl-induced contractions were recorded. Results. There was no significant difference between the contractile responsiveness to KCl, but maximum contractile responses (Emax) to carbachol and histamine were significantly reduced. Indomethacin, nimesulide, and DFU concentration dependently inhibited on KCl-induced contractions of gallbladder smooth muscle. Emax values of indomethacin, nimesulide, and DFU were significantly reduced in the peritonitis group compared with controls (P < 0.05). The inhibitor effects of nimesulide and DFU were considerably similar, but inhibitor effect of indomethacin was signifi- cantly less than that measured for nimesulide and DFU in both control and peritonitis groups (P < 0.05). Conclusions. The contraction responses to carbachol and histamine and relaxation responses to COX inhibitors on gallbladder smooth muscle are significantly decreased by peritonitis. Although the mechanism ofthe decrease in contraction and relaxation responses in CLP-induced peritonitis is completely unknown, we speculate that impaired smooth muscle responses may be related to an alteration in the regulation of receptor/postreceptor excitation-response coupling and/or through changes on Ca2 influx.en_US
dc.identifier.citationTemiz Kaya, T. Köylüoğlu, G. Karadaş, B. Turan, Y. Bağcıvan, İ. Ceran Özcan, C. Gökgöz, M. Ş. (2004). Effect of peritonitis on gallbladder smooth muscle contractility in guinea pigs.Journal of Surgical Research. 120, 219–224.en_US
dc.identifier.doi10.1016/j.jss.2003.12.010en_US
dc.identifier.endpage224en_US
dc.identifier.issn00224804
dc.identifier.startpage219en_US
dc.identifier.urihttps://hdl.handle.net/11616/7580
dc.identifier.volume120en_US
dc.language.isoenen_US
dc.publisherJournal of Surgical Researchen_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeritonitisen_US
dc.subjectGallbladderen_US
dc.subjectSmooth muscleen_US
dc.subjectIn vitroen_US
dc.titleEffect of peritonitis on gallbladder smooth muscle contractility in guinea pigsen_US
dc.typeArticleen_US

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