Liver pathology and cell proliferation after calcineurin ınhibitors and antiproliferative drugs following partial hepatectomy in rats

Basit Öğe Kaydı
dc.contributor.authorKırımlıoğlu, Hale
dc.contributor.authorKırımlıoğlu, Vedat
dc.contributor.authorYılmaz, Sezai
dc.contributor.authorÇoban, Sacid
dc.contributor.authorTürkmen, Emine
dc.contributor.authorAra, Cengiz
dc.date.accessioned2018-02-09T11:17:28Z
dc.date.available2018-02-09T11:17:28Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.descriptionTransplantation Proceedings, 38(2), 622–626.en_US
dc.description.abstractImmunosuppressants are the cornerstones of treatment after solid organ transplantation. This study investigated the pathology and cell proliferation following partial hepatectomy (PH) in rats undergoing immunosuppressive treatment. After 1 day, all rats were subjected to 70% PH. Groups A and B (n 10) received calcineurin inhibitors subcutaneously: either FK506 or cyclosporine (CyA). Groups C and D (n 10) received antiproliferative drugs: either mycophenolate mofetil (MMF) or sirolimus (SRL) by gavage. A control group (n 5) received 1 mL of tap water daily. On postoperative day 2, all rats were sacrificed to obtain liver tissue for pathologic examination. Using immunohistochemistry we separately examined the hepatectomy surface and the liver parenchyma. In the parenchyma, the Ki-67 indices were higher in the CyA and FK506 groups and lower in the SRL and MMF groups compared with controls (P .01). CyA had the highest and MMF the lowest values. On the hepatectomy surface, Ki-67 indices and TGF-alpha expressions were higher in the CyA group and lower in the SRL and MMF groups compared with the control group (P .01). Slightly higher values in the FK506 group were not significantly different compared with the control group (P .05). All groups other than FK506 showed prominent cholangiolar epithelial phenotypes compared with the control group. In the CyA and SRL groups, the number of cholangiolar cells was higher (P .01), and in the MMF group lower than in the control group (P .01). Among all groups, SRL had the highest values.en_US
dc.identifier.citationKırımlıoğlu, S. H., Kırımlıoğlu, V., Yılmaz, S., Türkmen, E., & Ara, C. (2006). Liver Pathology And Cell Proliferation After Calcineurin Inhibitors And Antiproliferative Drugs Following Partial Hepatectomy İn Rats. Transplantation Proceedings, 38(2), 622–626.en_US
dc.identifier.doi10.1016/j.transproceed.2005.12.097en_US
dc.identifier.endpage626en_US
dc.identifier.issue2en_US
dc.identifier.startpage622en_US
dc.identifier.urihttps://ac.els-cdn.com/S0041134505015939/1-s2.0-S0041134505015939-main.pdf?_tid=218099de-0d8a-11e8-8877-00000aab0f02&acdnat=1518174935_0df54f0040482ae659dc54944d39cf5c
dc.identifier.urihttps://hdl.handle.net/11616/8065
dc.identifier.volume38en_US
dc.language.isoenen_US
dc.publisherTransplantation Proceedings, 38(2), 622–626.en_US
dc.relation.ispartofTransplantation Proceedings, 38(2), 622–626.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleLiver pathology and cell proliferation after calcineurin ınhibitors and antiproliferative drugs following partial hepatectomy in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Makale Dosyası.pdf
Boyut:
190.86 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Tıp Fakültesi, Genel Cerrahi Anabilim Dalı Koleksiyonu