Evaluation of asymmetric dimethylarginine, nitric oxide levels and associated independent variables in obese and lean patients with polycystic ovarian syndrome

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dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridEngin-Ustun, Yaprak/0000-0002-1011-3848
dc.authoridTURKCUOGLU, ILGIN/0000-0002-8342-1956
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidUstun, Yaprak/KFQ-9767-2024
dc.contributor.authorTurkcuoglu, Ilgin
dc.contributor.authorEngin-Ustun, Yaprak
dc.contributor.authorTuran, Fahri
dc.contributor.authorKali, Zercan
dc.contributor.authorKarabulut, Aysun Bay
dc.contributor.authorMeydanli, Mutlu
dc.contributor.authorKafkasli, Ayse
dc.date.accessioned2024-08-04T20:58:44Z
dc.date.available2024-08-04T20:58:44Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective. To evaluate the asymmetric dimethylarginine (ADMA) and nitric oxide (NO) levels in obese and lean patients with polycystic ovarian syndrome (PCOS) and find out their relation with hormonal and metabolic parameters. Methods. Twenty-two obese, 18 lean patients with PCOS and 11 obese, 24 lean healthy control patients were enrolled prospectively. Plasma ADMA and NO levels and arginine/ADMA ratio were evaluated on 3rd day of menstrual cycle after at least 10 h overnight fasting. Results. Plasma ADMA, NO levels and arginine/ADMA ratio were similar in the groups. ADMA level did not correlate with the hormonal and metabolic parameters in patients with PCOS. However, NO correlated inversely with fasting insulin (r = -0.353, p = 0.041) and homeostasis model of insulin resistance (HOMA-IR) (r = -0.379, p = 0.027). Arginine/ADMA ratio also correlated inversely with fasting insulin (r = -0.339, p = 0.050). In multinomial regression analysis the risk of low NO was associated independently with high fasting insulin (OR = 1.19, 95% CI 1.001-1.42, p = 0.049) and high HOMA-IR in patients with PCOS (OR = 2.26, 95% CI 1.03-4.98, p = 0.042). Conclusions. Insulin resistance may be the underlying mechanism of endothelial dysfunction through NO pathway in PCOS.en_US
dc.identifier.doi10.3109/09513590.2010.507291
dc.identifier.endpage614en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue9en_US
dc.identifier.pmid20695761en_US
dc.identifier.startpage609en_US
dc.identifier.urihttps://doi.org/10.3109/09513590.2010.507291
dc.identifier.urihttps://hdl.handle.net/11616/103099
dc.identifier.volume27en_US
dc.identifier.wosWOS:000293599900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPCOSen_US
dc.subjectasymmetric dimethylarginineen_US
dc.subjectnitric oxideen_US
dc.subjectinsulin resistanceen_US
dc.subjectobesityen_US
dc.subjectcardiovascularen_US
dc.titleEvaluation of asymmetric dimethylarginine, nitric oxide levels and associated independent variables in obese and lean patients with polycystic ovarian syndromeen_US
dc.typeArticleen_US

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