False-positive reaction between syphilis and hepatitis C infection

Basit Öğe Kaydı
dc.authorwosidÖzerol, İbrahim Halil/ABI-8015-2020
dc.contributor.authorSonmez, E
dc.contributor.authorOzerol, IH
dc.contributor.authorSenol, M
dc.contributor.authorKizilkaya, N
dc.contributor.authorSahin, K
dc.contributor.authorOzbilge, H
dc.date.accessioned2024-08-04T20:58:51Z
dc.date.available2024-08-04T20:58:51Z
dc.date.issued1997
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThere are limited data about false-positive reactions against hepatitis C virus (HCV) in syphilitic patients and false-positive reactions against syphilis in the patients with HCV infection, The aim of this study was to demonstrate the false-positivity of syphilis in patients with HCV infection, the false-positivity of anti-HCV in patients with syphilis and the validity of the serological tests in such patients. Fifty patients with positive anti-HCV, 21 patients with positive VDRL and 50 healthy subjects were studied. Syphilis serology was determined by the Venereal Disease Research Laboratory (VDRL) test and microhemagglutination for T. pallidum (MHA-TP) test. Hepatitis C serology was determined by a second generation ELISA (Ortho Diagnostics) test for HCV antibody, and anti-HCV positive patients were tested for HCV RNA by polymerase chain reaction (PCR). All assays were performed on all subjects. Not only the false-positive VDRL reaction in the patients with HCV infection but also false-positive anti-HCV tests in syphilitic patients have been observed. Four patients with syphilis had positive anti-HCV and negative HCV-RNA, whereas 10% (5 of 50) of patients with hepatitis C infection had positive VDRL and these patients were negative for MHA-TP test, The rates of false-positivity of VDRL and anti-HCV were higher than within the control group (p<0.05). According to these data, positive anti-HCV in syphilitic patients and positive VDRL in chronic hepatitis C may be false-positive results with regard to the reaginic tests, Therefore, therapeutic measures should not be initiated without confirmation with a treponemal test or PCR. VDRL and HCV-ELISA tests may be interacted with IgM or IgG antibodies. This relationship should be investigated in further studies.en_US
dc.identifier.endpage727en_US
dc.identifier.issn0021-2180
dc.identifier.issue11en_US
dc.identifier.pmid9434808en_US
dc.identifier.startpage724en_US
dc.identifier.urihttps://hdl.handle.net/11616/103204
dc.identifier.volume33en_US
dc.identifier.wosWOS:000071442900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIsrael Journal Med Sciencesen_US
dc.relation.ispartofIsrael Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfalse-positive VDRLen_US
dc.subjectfalse-positive anti-HCVen_US
dc.subjectsyphilisen_US
dc.subjecthepatitis Cen_US
dc.titleFalse-positive reaction between syphilis and hepatitis C infectionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu