Biomechanical and biochemical evaluation of the effect of systemic application of omeprazole on the osseointegration of titanium implants

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dc.authoridTekin, Samet/0000-0001-8883-8307
dc.authoriddemirci, fatih/0000-0002-8744-5592
dc.authorwosidDundar, Serkan/V-8159-2018
dc.authorwosidTekin, Samet/GNH-3187-2022
dc.authorwosiddemirci, fatih/ABG-8682-2020
dc.contributor.authorTekin, Samet
dc.contributor.authorDundar, Serkan
dc.contributor.authorDemirci, Fatih
dc.contributor.authorBozoglan, Alihan
dc.contributor.authorYildirim, Tuba Talo
dc.contributor.authorGunes, Nedim
dc.contributor.authorAcikan, Izzet
dc.date.accessioned2024-08-04T20:57:16Z
dc.date.available2024-08-04T20:57:16Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground This study aimed to investigate the effects of systemic omeprazole treatment on the osseointegration of titanium implants. Material and methods After surgical insertion of titanium implants into the metaphyseal part of rats' both right and left tibial bones, the animals were randomly divided into three equal groups: control (n = 8), omeprazole dosage-1 (n = 8) (OME-1), and omeprazole dosage-2 (n = 8) (OME-2) and totally 48 implants were surgically integrated. The rats in the control group received no treatment during the four-week postoperative experimental period. In the OME-1 and OME-2 groups, the rats received omeprazole in doses of 5 and 10 mg/kg, respectively, every 3 days for 4 weeks. After the experimental period, the rats were euthanized. One rat died in each group and the study was completed with seven rats in each group. Blood serum was collected for biochemical analysis, and the implants and surrounding bone tissue were used for biomechanical reverse-torque analysis. In the biomechanical analysis, implants that were not properly placed and were not osseointegrated were excluded from the evaluation. Results One-way analysis of variance and Tukey's honestly significant difference test and Student's t test were used for statistical analysis. The reverse-torque test (control (n = 9), OME-1 (N = 7), and OME-2 (n = 7)) analysis of biochemical parameters (alkaline phosphatase, calcium, phosphorus, aspartate aminotransferase, alanine amino transferase, urea, and creatinine) revealed no significant differences between the groups (control (n = 7), OME-1 (N = 7), and OME-2 (n = 7)) (P > 0.05). Conclusions Omeprazole had no biomechanical or biochemical effects on the osseointegration process of titanium implants.en_US
dc.description.sponsorshipFirat University Scientific Research Project Foundation Department, Elazig, Turkiye [DHF.19.12]en_US
dc.description.sponsorshipThis study supported by Firat University Scientific Research Project Foundation Department, Elazig, Turkiye with the project number DHF.19.12.en_US
dc.identifier.doi10.1186/s40729-021-00310-5
dc.identifier.issn2198-4034
dc.identifier.issue1en_US
dc.identifier.pmid33843027en_US
dc.identifier.urihttps://doi.org/10.1186/s40729-021-00310-5
dc.identifier.urihttps://hdl.handle.net/11616/102488
dc.identifier.volume7en_US
dc.identifier.wosWOS:000639043100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Japan Kken_US
dc.relation.ispartofInternational Journal of Implant Dentistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOsseointegrationen_US
dc.subjectProton pump inhibitorsen_US
dc.subjectOmeprazoleen_US
dc.subjectBone implant connectionen_US
dc.subjectBone implant contacten_US
dc.titleBiomechanical and biochemical evaluation of the effect of systemic application of omeprazole on the osseointegration of titanium implantsen_US
dc.typeArticleen_US

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