Therapeutic Effects of Plasmapheresis on Acute Exacerbations of Chronic Hepatitis B Infection

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dc.authoridHarputluoglu, Muhsin Murat Muhip/0000-0002-9415-147X
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridSARICI, Ahmet/0000-0002-5916-0119
dc.authoridCagin, Yasir Furkan/0000-0002-2538-857X
dc.authorwosidTemizkan, Ayşe/AAD-9705-2020
dc.authorwosidHarputluoglu, Muhsin Murat Muhip/ABI-3094-2020
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidSARICI, Ahmet/ABI-7512-2020
dc.authorwosidCagin, Yasir Furkan/ABI-2709-2020
dc.contributor.authorBilgic, Yilmaz
dc.contributor.authorAkbulut, Sami
dc.contributor.authorCengiz, Ayse
dc.contributor.authorSarici, Ahmet
dc.contributor.authorCagin, Yasir
dc.contributor.authorHarputluoglu, Murat
dc.date.accessioned2024-08-04T21:02:16Z
dc.date.available2024-08-04T21:02:16Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective In this study, we aimed to demonstrate the effectiveness of plasmapheresis therapy in patients with acute exacerbation of chronic Hepatitis B (CHB) infection. Methods We selected 48 patients with acute exacerbation of CHB infection who were treated by plasmapheresis in our intensive care unit between 2009 and 2016. The patients' demographic characteristics and biochemical and hematological parameters, which were recorded before and after plasmapheresis, were assessed, and the effect of plasmapheresis on the course of patients' treatment was examined. The patients were also divided into three groups according to their clinical course (discharged: 24; transplanted: six; exitus: eight). The patients were further divided into four groups and compared based on the underlying causes that led to the exacerbation (spontaneous exacerbation: 25; caused by immunosuppressive drugs: nine; hepatotoxic drugs: six; other agents: eight). Results We observed significant improvements in terms of international normalized ratio (INR), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), total bilirubin, direct bilirubin, blood urea nitrogen (BUN), ammonia, and the Model for End-Stage Liver Disease (MELD) score after plasmapheresis therapy. However, there was no significant improvement in hemoglobin (Hb), white blood cell (WBC) count, platelets, albumin, and lactate values. Also, INR, ALP, and ALT values were found to be significantly correlated with transplants and exitus in patients. Conclusion Plasmapheresis therapy is a reliable treatment method that provides clinical recovery and improvement in laboratory parameters in patients with exacerbation of CHB infection.en_US
dc.identifier.doi10.7759/cureus.12779
dc.identifier.issn2168-8184
dc.identifier.issue1en_US
dc.identifier.pmid33628651en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.12779
dc.identifier.urihttps://hdl.handle.net/11616/104606
dc.identifier.volume13en_US
dc.identifier.wosWOS:000609028300002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofCureus Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectchronic hepatitis ben_US
dc.subjectexecarbationen_US
dc.subjectplasmapheresisen_US
dc.subjectliver transplantationen_US
dc.titleTherapeutic Effects of Plasmapheresis on Acute Exacerbations of Chronic Hepatitis B Infectionen_US
dc.typeArticleen_US

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