The protective effect of aminoguanidine on random pattern skin flap survival

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dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAydoğan, Nilay/0000-0002-5510-7804
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidAydoğan, Nilay/ABH-9450-2020
dc.contributor.authorAydogan, Hakan
dc.contributor.authorGuerlek, Ali
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorAydogan, Nilay
dc.contributor.authorAcet, Ahmet
dc.date.accessioned2024-08-04T21:02:09Z
dc.date.available2024-08-04T21:02:09Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Distal flap necrosis resulting from ischemia is a serious problem, and increases the cost of treatment. Reactive oxygen radicals (ROS) play an important role in tissue injury and ischemia, and may lead to partial or complete flap necrosis. Aminoguanidine (AG), a potent antioxidant, prevents ROS formation and lipid peroxidation. Besides, AG inhibits inducible nitric oxide synthase (iNOS) leading to decreased generation of nitric oxide (NO). Material and Methods: Rats were randomly divided into three groups: Control, flap elevated saline group, and AG treated group. A caudally based rectangular flap, 3 x 10-cm was elevated on the back of the rats. Flap viability was evaluated 7 days after the initial operation, measuring necrotic areas and total flap areas by computer-assisted planimetry. Malondialdehyde (MDA), NO, glutathione (GSH), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) levels were measured in flap skin tissue to observe the effects of AG. Results: Rate of flap necrosis and MDA, NO levels were higher in the saline group compared to the control group, while GSH, GSH-Px, and SOD enzyme activities were reduced. AG administration reduced lipid peroxidation, NO generation and increased GSH, GSH-Px, SOD enzyme activities. Furthermore, it significantly reduced the rate of flap necrosis when compared with the saline group. Conclusion: We believe that AG, a potent antioxidant and iNOS inhibitor, has beneficial effects to improve skin flap viability when distal flap necrosis is a potential complication in longer flaps.en_US
dc.identifier.endpage43en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue1en_US
dc.identifier.startpage36en_US
dc.identifier.urihttps://hdl.handle.net/11616/104511
dc.identifier.volume27en_US
dc.identifier.wosWOS:000254120800008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectarninoguanidineen_US
dc.subjectsurgical flapsen_US
dc.subjectreactive oxygen speciesen_US
dc.subjectmalondialdehydeen_US
dc.titleThe protective effect of aminoguanidine on random pattern skin flap survivalen_US
dc.typeArticleen_US

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