Malformations of cortical development and epilepsy

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dc.contributor.authorGuengoer, Serdal
dc.contributor.authorYalnizoglu, Dilek
dc.contributor.authorTuranli, Guezide
dc.contributor.authorSaatci, Isil
dc.contributor.authorErdogan-Bakar, Emel
dc.contributor.authorTopcu, Meral
dc.date.accessioned2024-08-04T20:59:55Z
dc.date.available2024-08-04T20:59:55Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMalformations of cortical development (MCD) form a spectrum of lesions produced by insult to the developing neocortex. Clinical presentation and electrophysiologic findings of MCD are variable and depend on the affected cortical area. We evaluated epilepsy, EEG, and response to antiepileptic treatment in patients with MCD with respect to the neuroimaging findings. We studied 101 patients, ranging between I month and 19 years of age. Fifty-four patients were diagnosed with polymicrogyria (PMG), 23 patients with lissencephaly, 12 patients with schizencephaly, and 12 patients with heterotopia. With regards to epilepsy and seizure type, 72/101 (71.3%) patients had epilepsy, and 62/101 (61.4%) patients presented with seizures. Overall, 32.7% of patients had generalized seizures, and 25.7% had complex partial seizures. Mean age at the onset of seizures was 2.7 +/- 3.4 years. The onset of epilepsy tended to be younger in patients with lissencephaly and older in patients with heterotopias. Of the cases, 79.2% had abnormal EEG (56.3% with epileptiform abnormality, 22.9% with non-epileptiform abnormality). EEG was abnormal in 44.9% (13/29) of the cases without epilepsy. EEG showed bilateral synchronous and diffuse epileptiform discharges in 90% of patients with lissencephaly. Patients with schizencephaly had mostly focal epileptiform discharges. Heterotopia cases had a high rate of EEG abnormalities (72.7%). Patients with PMG had epileptiform abnormality in 59.5% of the cases. Patients with heterotopias and PMG achieved better seizure control in comparison with the other groups. In conclusion, epilepsy is the most common problem in MCD. Epilepsy and EEG findings of patients with MCD are variable and seem to be correlated with the extent of cortical involvement.en_US
dc.description.sponsorshipFIC NIH HHS [D43TW05807] Funding Source: Medlineen_US
dc.identifier.endpage140en_US
dc.identifier.issn0041-4301
dc.identifier.issue2en_US
dc.identifier.pmid17907511en_US
dc.identifier.startpage131en_US
dc.identifier.urihttps://hdl.handle.net/11616/103641
dc.identifier.volume49en_US
dc.identifier.wosWOS:000248902300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmalformations of cortical developmenten_US
dc.subjectlissencephalyen_US
dc.subjectheterotopiaen_US
dc.subjectpolymicrogyriaen_US
dc.subjectschizencephalyen_US
dc.subjectepilepsyen_US
dc.subjectMRIen_US
dc.subjectEEGen_US
dc.titleMalformations of cortical development and epilepsyen_US
dc.typeArticleen_US

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