Decreased nitric oxide production in primary open-angle glaucoma

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720;
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidEvereklioğlu, Cem/A-5370-2018
dc.contributor.authorDoganay, S
dc.contributor.authorEvereklioglu, C
dc.contributor.authorTurkoz, Y
dc.contributor.authorEr, H
dc.date.accessioned2024-08-04T20:57:35Z
dc.date.available2024-08-04T20:57:35Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE. Raised intraocular pressure (IOP) is the major risk factor responsible for optic nerve damage in primary open-angle glaucoma (POAG). The trabecular meshwork acts as a valve in aqueous outflow and relaxes with nitric oxide (NO) agonists. Since NO is synthesized by endothelium and smooth muscle elsewhere in the body, this study investigated the NO levels in the aqueous humor of patients with POAG compared with cataract patients. MATERIALS AND METHODS. Aqueous humor samples were taken by paracentesis from 16 consecutive patients with POAG (9 male and 7 female; mean age 69.0 +/- 3.4 yrs) and 14 age and sex-matched controls with cataract (8 male and 6 female; mean age 66.7 +/- 4.1 yrs) during elective surgery. As an indicator for NO, aqueous total nitrite levels (end - product of NO) were measured by Greiss reaction. The Mann-Whitney U test was used for statistical analysis and P <0.05 was considered significant. RESULTS. The mean age and sex in two groups were comparable. The mean aqueous humor NO levels were significantly (P = 0.001) lower in patients with glaucoma (72.72 +/- 11.21 mumol/L) than in patients with cataract and no glaucoma (86.92 +/- 11.23 mumol/L). CONCLUSIONS. Decreased NO production in patients with POAG indicates that NO-producing cells may be lost as the disease progresses. The control of NO levels in the eye might be a therapeutic target in glaucoma.en_US
dc.identifier.doi10.1177/112067210201200109
dc.identifier.endpage48en_US
dc.identifier.issn1120-6721
dc.identifier.issn1724-6016
dc.identifier.issue1en_US
dc.identifier.pmid11936443en_US
dc.identifier.startpage44en_US
dc.identifier.urihttps://doi.org/10.1177/112067210201200109
dc.identifier.urihttps://hdl.handle.net/11616/102750
dc.identifier.volume12en_US
dc.identifier.wosWOS:000174175700009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWichtig Publen_US
dc.relation.ispartofEuropean Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnitric oxideen_US
dc.subjectaqueous humoren_US
dc.subjectglaucomaen_US
dc.titleDecreased nitric oxide production in primary open-angle glaucomaen_US
dc.typeArticleen_US

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