Effectiveness and safety of lmwh treatment in patients with cancer diagnosed with non-high-riskvenous thromboembolism: Turkish observational study (trebeca)
Yükleniyor...
Dosyalar
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SAGE PUBLICATIONS INC, 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
We compared the efficacy and safety of low-molecular-weight heparins (LMWHs) in patients with cancer who are at low risk of venous thromboembolism (VTE). Patients were treated by medical oncologists in Turkey at 15 sites, where they were enrolled and followed up for a period of 12 months. Due to the study design, there was no specific treatment protocol for LMWH. Primary end points were efficacy and the time to change in VTE status. Of the included 250 patients, 239 (95.6%), 176 (70.4%), 130 (52.0%), and 91 (36.4%) completed their day 15, month 3, month 6, and month 12 visits, respectively. Number of patients treated with enoxaparin, bemiparin, and tinzaparin were 133, 112, and 5, respectively. Anticoagulant therapy provoked thrombus resolution in 1.2% and 12.7% of patients using enoxaparin and bemiparin, respectively (P = .004). Thrombus resolution was observed in 81 more patients at month 3 visit. This ratio was 35 (40.2%) of 87 and 46 (54.1%) of 85 patients administered enoxaparin and bemiparin at the third visit, respectively (P = .038). Thrombus resolution was observed in 21 more patients during month 6 visit. This ratio was 5 (7.7%) of 65 and 15 (23.4%) of 64 patients administered enoxaparin and bemiparin at the fourth visit, respectively (P = .022). The LMWH was discontinued in only 2 patients due to gastrointestinal bleeding. This pioneering study shows bemiparin is more effective than enoxaparin in thrombosis resolution and has a similar tolerability profile.
Açıklama
Anahtar Kelimeler
Molecular-Weıght Heparın, Cell Lung-Cancer, Clınıcal-Practıce, Preventıon, Thrombosıs, Chemotherapy, Bemıparın, Prophylaxıs, Therapy, Update
Kaynak
Clınıcal and applıed thrombosıs-hemostasıs
WoS Q Değeri
Scopus Q Değeri
Cilt
24
Sayı
6
Künye
Elkıran, ET. (2018). Effectiveness and safety of lmwh treatment in patients with cancer diagnosed with non-high-riskvenous thromboembolism: Turkish observational study (trebeca). Cilt:24 Sayı:6, 973-979 ss.
