The role of p53, Bcl-2 and Ki-67 in premalignant cervical lesions and cervical cancer

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dc.authoridAtabekoglu, Cem Somer/0000-0003-0264-0709
dc.authoridKankaya, Duygu/0000-0002-3913-9224
dc.authoridOrtac, Ugur Firat/0000-0001-6735-5760
dc.authoridGUNGOR, Mete/0000-0001-8010-4181
dc.authoridTURKCUOGLU, ILGIN/0000-0002-8342-1956
dc.authorwosidAtabekoglu, Cem Somer/AAI-8767-2020
dc.authorwosidGungor, Mete/X-4933-2018
dc.authorwosidKankaya, Duygu/T-4145-2019
dc.authorwosidOrtac, Ugur Firat/AAI-5118-2020
dc.contributor.authorTuerkcueoglu, I.
dc.contributor.authorTezcan, S.
dc.contributor.authorKaygusuz, G.
dc.contributor.authorAtabekoglu, C. Somer
dc.contributor.authorOrtac, F.
dc.contributor.authorGuengoer, M.
dc.contributor.authorKankaya, D.
dc.date.accessioned2024-08-04T21:02:12Z
dc.date.available2024-08-04T21:02:12Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to determine the role of p53, Bcl-2 and Ki-67 expression in the carcinogenesis of cervical carcinoma and aggressiveness of cervical intraepithelial neoplasia (CIN). Methods: The pathology specimens of 63 patients with a diagnosis of normal squamous epithelium (22 cases), CIN I (14), CIN II (5), CIN III (8) and squamous cell carcinoma (14) were evaluated immunohistochemically for the expression of p53, Bcl-2 and Ki-67 in paraffin sections. Results: The expression of p53 and Ki-67 increased proportionally to the grade of CIN and cervical cancer, but only the increase of p53 expression was statistically significant (p = 0.002). There was no significant correlation between Bcl-2 expression and premalignant and malignant cervical lesions. Conclusion: p53 expression may have a role in the carcinogenesis of squamous cell cervical carcinoma whereas Bcl-2 expression has no role. Ki-67 expression can not be used in determining the aggressiveness of CIN lesions.en_US
dc.identifier.endpage293en_US
dc.identifier.issn0392-2936
dc.identifier.issue4en_US
dc.identifier.pmid17713095en_US
dc.identifier.startpage290en_US
dc.identifier.urihttps://hdl.handle.net/11616/104568
dc.identifier.volume28en_US
dc.identifier.wosWOS:000248192500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcervical intraepithelial neoplasiaen_US
dc.subjectcervical canceren_US
dc.subjectp53en_US
dc.subjectBcl-2en_US
dc.subjectKi-67en_US
dc.titleThe role of p53, Bcl-2 and Ki-67 in premalignant cervical lesions and cervical canceren_US
dc.typeArticleen_US

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