Factors affecting the accuracy of 18F-FDG PET/CT in detecting additional tumor foci in breast cancer

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dc.authoridSimsek, Arife/0000-0002-4807-3597
dc.authorwosidSimsek, Arife/AAB-3245-2021
dc.contributor.authorSimsek, A.
dc.contributor.authorKutluturk, K.
dc.contributor.authorComak, A.
dc.contributor.authorAkatli, A.
dc.contributor.authorKekilli, E.
dc.contributor.authorUnal, B.
dc.date.accessioned2024-08-04T20:58:51Z
dc.date.available2024-08-04T20:58:51Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE To evaluate the effectiveness of F-18-FDG PET/CT for detecting additional tumor foci in breast cancer. MATERIAL-METHOD The data were reviewed retrospectively of 232 women who underwent F-18-FDG PET/CT examination prior to breast cancer surgery between January 2013 and December 2018. RESULTS Additional tumor foci were suspected in 95 cases on F-18-FDG PET/ CT, which were confirmed by histopathological analysis in 81 cases. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of F-18-FDG PET/CT in detection of additional tumor foci were 77.7%, 79.48%, 66.3%, 87.32%, and 79.23%, respectively. The false negative and false positive rates were 22.22% and 20.51%, respectively. In univariate analysis, only the patient's age was positively associated with accuracy of F-18-FDG PET/CT in detecting additional tumor foci. The accuracy was lower in women aged <= 50 years, with a substantial increase in false positive findings in women in that age group. CONCLUSIONS F-18-FDG PET/CT alone cannot replace conventional diagnostic procedures for evaluating additional tumor foci in breast cancer, as a substantial increase in false positive findings is recorded with this method in women aged <= 50 years old.en_US
dc.identifier.endpage214en_US
dc.identifier.issn1105-3992
dc.identifier.issue2en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://hdl.handle.net/11616/103199
dc.identifier.volume38en_US
dc.identifier.wosWOS:000627732600009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAthens Medical Socen_US
dc.relation.ispartofArchives of Hellenic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast canceren_US
dc.subjectMulticentricityen_US
dc.subjectMultifocalityen_US
dc.subjectPET/CTen_US
dc.subjectTumor focien_US
dc.titleFactors affecting the accuracy of 18F-FDG PET/CT in detecting additional tumor foci in breast canceren_US
dc.typeArticleen_US

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