Melatonin ameliorates tacrolimus FK 506 s induced immunosupressive effect in rat liver
| dc.authorid | 109416 | en_US |
| dc.contributor.author | Ara, Cengiz | |
| dc.contributor.author | Bay Karabulut, Aysun | |
| dc.date.accessioned | 2017-09-07T10:37:28Z | |
| dc.date.available | 2017-09-07T10:37:28Z | |
| dc.date.issued | 2009 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Tacrolimus (FK-506) is a powerful immunosuppressive agent that modulates neutrophil infiltration during inflammation. In this study, we sought to investigate the effects of melatonin on malondialdehyde (MDA), nitric oxide (NO), interleukin (IL)-6, and tumor necrosis factor-alpha (TNF-alpha) to oppose the negative effects of the immunosupressant FK-506. Group A was sham; group B, tacrolimus (1 mg/kg/d subcutaneously); and Group C received tacrolimus (1 mg/kg/d plus melatonin). All tissues underwent histopathologic examination. The MDA level in group B increased 53% compared with the sham group (P .001); in group C, the MDA level decreased 16% compared with group B (P .05). While TNF-alpha in group B increased 68.8% compared with the sham group (P .001) and in group C it decreased 63.5% compared with the sham group. The IL-6 level in group B increased 81%; in group C, it decreased 13% compared with group B. NO levels in group B increased 48% compared with the sham group and increased by 15% in group B compared with group C. Thus melatonin may serve as a protective agent against the side effects of tacrolimus. | en_US |
| dc.identifier.citation | Ara, C. Bay Karabulut, A. (2009). Melatonin ameliorates tacrolimus FK 506 s induced immunosupressive effect in rat liver. 41, 1875–1877. | en_US |
| dc.identifier.doi | 10.1016/j.transproceed.2008.12.035 | en_US |
| dc.identifier.endpage | 1877 | en_US |
| dc.identifier.startpage | 1875 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/7728 | |
| dc.identifier.volume | 41 | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Transplant Proc | en_US |
| dc.relation.ispartof | Transplant Proc | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Melatonin ameliorates tacrolimus FK 506 s induced immunosupressive effect in rat liver | en_US |
| dc.type | Article | en_US |
