Use of caffeic acid phenethyl ester to prevent sodium-selenite-induced cataract in rat eyes

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidEvereklioğlu, Cem/A-5370-2018
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorDoganay, S
dc.contributor.authorTurkoz, Y
dc.contributor.authorEvereklioglu, C
dc.contributor.authorEr, H
dc.contributor.authorBozaran, M
dc.contributor.authorOzerol, E
dc.date.accessioned2024-08-04T21:02:20Z
dc.date.available2024-08-04T21:02:20Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To investigate whether caffeic acid phenethyl ester (CAPE) prevents sodium-selenite-induced cataract. Setting: Department of Ophthalmology and Biochemistry, Inonu University Medical Faculty, Turgut Ozal Medical Center, Research Hospital, Malatya, Turkey. Methods: Sixty Spraque-Dawley rat litters were randomized into 3 groups. In Group 1 (n = 18), sodium selenite (30 nmol/g body weight) was injected subcutaneously on postpartum day 10. In Group 2 (n = 22), subcutaneous CAPE (15 mumol/kg) and sodium selenite (30 nmol/g body weight) were injected on postpartum day 10. The CAPE dose was continued subcutaneously for 3 days after the initial injection. Only subcutaneous saline was injected in Group 3 (control, n = 20). The development of cataract was assessed weekly, and its density was graded by slitlamp biomicroscopy and photography. Removed rat lenses were analyzed for glutathione (GSH) and malondialdehyde (MDA, marker of lipid peroxidation). Results: Group 2 rats had clear lenses or minor cataract. All Group 1 rats developed more severe cataract or complete opacification. The between-group difference was statistically significant (P < .05). All control lenses (Group 3) were clear. The mean GSH level in Group 1 (4.49 mumol/g wet weight +/- 0.93 [SD]) was significantly lower than that in Group 2 (8.63 +/- 0.88 mumol/g wet weight) (P < .05) and controls (10.76 +/- 1.97 mumol/g wet weight) (P < .05). The mean MDA level in Group 1 (8.54 +/- 1.31 nmol/g wet weight) was significantly higher than that in Group 2 (5.23 +/- 0.84 nmol/g wet weight) (P < .05) and controls (4.19 +/- 0.81 nmol/g wet weight) (P < .05). Conclusion: Caffeic acid phenethyl ester effectively suppressed cataract formation in rats. The protective effect was supported by lower GSH and higher MDA levels in Group 1 than in Group 2, suggesting the antioxidant efficacy of this agent. Since CAPE has no known harmful effect on normal cells, it may be beneficial in clinical use in humans. (C) 2002 ASCRS and ESCRS.en_US
dc.identifier.doi10.1016/S0886-3350(02)01242-7
dc.identifier.endpage1462en_US
dc.identifier.issn0886-3350
dc.identifier.issue8en_US
dc.identifier.pmid12160820en_US
dc.identifier.startpage1457en_US
dc.identifier.urihttps://doi.org/10.1016/S0886-3350(02)01242-7
dc.identifier.urihttps://hdl.handle.net/11616/104690
dc.identifier.volume28en_US
dc.identifier.wosWOS:000177417200035en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Cataract and Refractive Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiochemical-Changesen_US
dc.subjectPropolis Extracten_US
dc.subjectLensen_US
dc.subjectOpacificationen_US
dc.subjectGlutathioneen_US
dc.subjectCellsen_US
dc.subjectCapeen_US
dc.subjectTransformationen_US
dc.subjectSuppressionen_US
dc.subjectInhibitionen_US
dc.titleUse of caffeic acid phenethyl ester to prevent sodium-selenite-induced cataract in rat eyesen_US
dc.typeArticleen_US

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