Effect of hemostatic agent Ankaferd on growth factors and hydroxyproline which play a role in wound healing

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidSarac, Gulbahar/ABF-3119-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorSezgin, Sevgi
dc.contributor.authorSarac, Gulbahar
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorSenol, Mustafa
dc.date.accessioned2024-08-04T20:58:30Z
dc.date.available2024-08-04T20:58:30Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: There have been a lot of topical and systemic agents to provide an ideal scar formation and decrease the periods of wound healing process by affecting the factors of healing (inflammatory cells, thrombocytes, extracellular matrix etc.). Ankaferd is an extract used as a hemostatic agent which is prepared in certain ratios of five herbal contents which are used in traditional Turkish medicine. In our study, we observed the effects of Ankaferd on wound healing. Materials and Methods: So that, the wounds were created with 8 mm punch biopsy on the back of 36 rats which were seperated into 4 groups of 9 rats. No treatment was done in Group D which is the control group while Group A took topical Ankaferd treatment twice a day, Group B treated with silver sulfadiazine twice a day, and Group C put on base cream twice a day which did not include any active agent. The rats were followed for 15 days macroscopically on 0, 3, 7 ve 15th days by taking biopsies and the levels of hydroxyproline, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) were analysed from the tissue. Results: Th ere were no significiant differences by means of EGF and PDGF levels between the all groups. The only significiantly lower growth factor was VEGF in the silver sulfadiazine group. The wound healing process was determined faster in silver sulfadiazine and Ankaferd groups. There was no significiant difference in hydroxyproline levels between these groups and the hydroxyproline levels were significiantly higher in control group. At the end of our study, it was detected that Ankaferd accelerated the healing process similar to silver sulfadiazin, in comparison to control and base cream groups according to the macroscopic results.en_US
dc.identifier.doi10.5578/aai.8938
dc.identifier.endpage32en_US
dc.identifier.issn1308-9234
dc.identifier.issue1en_US
dc.identifier.startpage26en_US
dc.identifier.urihttps://doi.org/10.5578/aai.8938
dc.identifier.urihttps://hdl.handle.net/11616/102898
dc.identifier.volume13en_US
dc.identifier.wosWOS:000420894600004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherBilimsel Tip Yayinevien_US
dc.relation.ispartofAstim Allerji Immunolojien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkaferden_US
dc.subjectwound healingen_US
dc.titleEffect of hemostatic agent Ankaferd on growth factors and hydroxyproline which play a role in wound healingen_US
dc.typeArticleen_US

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