Fabrication and characterization of high molecular mass tmpe-based polyurethane wound dressing materials containing allantoin and gentamicin by electrospinning

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dc.authoridGürses, Canbolat/0000-0002-4085-0224
dc.authorwosidGürses, Canbolat/AAA-6825-2019
dc.contributor.authorCakmen, Ayse Basak
dc.contributor.authorNoma, Samir Abbas Ali
dc.contributor.authorGurses, Canbolat
dc.contributor.authorKoytepea, Suleyman
dc.contributor.authorAtes, Burhan
dc.contributor.authorYilmaz, Ismet
dc.date.accessioned2024-08-04T20:58:49Z
dc.date.available2024-08-04T20:58:49Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, biocompatible, antibacterial and high mechanical strength polyurethane-based wound dressing materials were prepared by using the electrospinning technique. In addition, allantoin and gentamicin which will contribute to wound healing, were incorporated into these fiber materials. Polyurethane structures containing trimethylolpropane ethoxylate (TMPE) with 2 different molecular weights were synthesized. TMPE-based polyurethanes/polycaprolactone (1:3) blends were also prepared by adding 1% gentamicin and 10% allantoin and they were knitted by the electrospinning method and turned into a wound dressing material. After this stage, chemical structure, morphological, thermal and mechanical properties, flexibility, antibacterial effect, in vitro biocompatibility, cell adhesion tests, allantoin release level, and biodegradability of the prepared wound dressing materials were performed. The prepared fiber materials exhibited antibacterial properties and 80% cell viability, approximately. In addition, the obtained wound dressing materials showed high mechanical strength and ideal gas permeability. For this reason, it offers an ideal alternative for closing wounds.en_US
dc.description.sponsorshipInonu University Scientific Research Funden_US
dc.description.sponsorshipAcknowledgment This work was financially supported by Inonu University Scientific Research Fund.en_US
dc.identifier.doi10.37819/nanofab.8.1787
dc.identifier.issn2299-680X
dc.identifier.urihttps://doi.org/10.37819/nanofab.8.1787
dc.identifier.urihttps://hdl.handle.net/11616/103195
dc.identifier.volume8en_US
dc.identifier.wosWOS:001193689600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherEurasia Acad Publ Group (Eapg)en_US
dc.relation.ispartofNanofabricationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiomaterialsen_US
dc.subjectWound dressing materialen_US
dc.subjectBiocompatibilityen_US
dc.subjectPU fibersen_US
dc.subjectElectrospinningen_US
dc.titleFabrication and characterization of high molecular mass tmpe-based polyurethane wound dressing materials containing allantoin and gentamicin by electrospinningen_US
dc.typeArticleen_US

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