INVESTIGATING THE THERAPEUTIC EFFECTS OF FLAVONOID-STRUCTURED HESPERIDIN IN ACUTE BURN TRAUMAS

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dc.authoridOguzturk, Hakan/0000-0002-9800-1428
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridTurtay, Muhammet Gokhan/0000-0002-1728-8237
dc.authoridYucel, Neslihan/0000-0001-5845-2614
dc.authoridGurbuz, Sukru/0000-0003-2616-0304
dc.authorwosidOguzturk, Hakan/AAC-3915-2021
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidFirat, Cemal/D-1292-2012
dc.authorwosidTurtay, Muhammet Gokhan/ABG-7401-2020
dc.authorwosidTaşlıdere, Aslı/ABI-8274-2020
dc.authorwosidoguzturk, hakan/Q-6242-2019
dc.authorwosidYucel, Neslihan/ABI-3412-2020
dc.contributor.authorOguzturk, Hakan
dc.contributor.authorCiftci, Osman
dc.contributor.authorTaslidere, Asli
dc.contributor.authorTurtay, Muhammet Gokhan
dc.contributor.authorGurbuz, Sukru
dc.contributor.authorBasak, Nese
dc.contributor.authorFirat, Cemal
dc.date.accessioned2024-08-04T20:59:40Z
dc.date.available2024-08-04T20:59:40Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOne of the flavonoids, Hesperidin might be beneficial in the treatment of burn injuries. In this study, it was aimed to investigate the effect of Hesperidin in the treatment of burn injuries. In this study, 32 male Sprague Dawley rats were randomized to four groups after local burn development: Group I (Control); rats were left to secondary healing without treatment, Group 2 (Bacitracin group); rats were treated with pomade locally (Bacitracin neomycin sulfate), Group 3(Hesperidin) were treated with Hesperidin for 14 days without Bacitracin, and Group 4(Bacitracin+Hesperidin); local pomade treatment and Hesperidin 50 mg/kg were administered by gastric gavage once a day for 14 days. Skin biopsies and blood samples were collected on days 3, 7,14 relative to burn induction. IL-1 beta and TNF-alpha studies from blood samples and histopathological inspections from tissue biopsies were performed. In Hesperidin + Bacitracin group, 3rd, 7th and 14th days significant reduction in necrosis in the epidermis and dermis, in the 3rd and 14th days little mononuclear cell infiltration that were detected. In this group, on day 14, mononuclear cell infiltration decreased significantly and fairly small amount of vascular congestion was observed on day 7. On day 14 of Hesperidin+Bacitracin group, no congestion or hemorrhage was observed. According to histopathological inspection, it was observed that Hesperidin is effective in burn injury treatment but the best results were observed in Hesperidin+Bacitracin group. It was detected that the most significant decrease in IL-1 beta and TNF-alpha levels in time was in Hesperidin+Bacitracin group. In conclusion, Hesperidin was effective on burn wound healing. Moreover, the effect could be amplified when combined with topical antibiotics in the early stage of burn wound healing.en_US
dc.identifier.endpage5454en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue8en_US
dc.identifier.startpage5446en_US
dc.identifier.urihttps://hdl.handle.net/11616/103428
dc.identifier.volume27en_US
dc.identifier.wosWOS:000444528000031en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBurnen_US
dc.subjectHesperidinen_US
dc.subjectExperimentalen_US
dc.titleINVESTIGATING THE THERAPEUTIC EFFECTS OF FLAVONOID-STRUCTURED HESPERIDIN IN ACUTE BURN TRAUMASen_US
dc.typeArticleen_US

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