The effects of synthetic organoselenium compounds on nitric oxide in DMBA - induced rat liver

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dc.authoridYılmaz, İsmet/0000-0002-7204-1050;
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorBayraktar, Nihayet
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorGok, Yetkin
dc.contributor.authorYilmaz, Ismet
dc.date.accessioned2024-08-04T21:02:02Z
dc.date.available2024-08-04T21:02:02Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDMBA (7,12-dimethylbenz[a]anthracene) is known to generate DNA-reactive species during their metabolism, which may enhance oxidative stress in cells. Since selenium is known as a non-enzymic antioxidant, health problems induced by many environmental pollutants, have stimulated the evaluation of relative antioxidant potential of selenium and synthetic organoselenium compounds. Therefore, we aimed to evaluate chemopreventive potential of synthetic organoselenium compounds by monitoring level of liver nitric oxide. In this study, adult female Wistar rats were treated with DMBA and the novel organoselenium compounds (Se I) and (Se II) in the determined doses. DMBA-induced in rats, the effects of organoselenium compounds on nitric oxide levels in rat liver was studied. In this study, it has been observed a statistically significant increase in (Nitric Oxide) levels for the liver of rat exposed to DMBA (p<0.05). However with administration of Se I and Se II there was a statistically significant decrease in NO levels (p<0.05). The ability of the organoselenium compounds to prevent oxidative damage induced by DMBA in rat livers was rationalized. Protection against nitric oxide measured in Se I and Sell treated groups were provided by synthesized organoselenium compounds. Se I and Sell both provided chemoprevention against DMBA-induced oxidative stress in rat liver.en_US
dc.description.sponsorshipTechnological and Scientific Research Council of Turkey [TUBITAK TBAG-2259 (102T185)]en_US
dc.description.sponsorshipWe thank to Technological and Scientific Research Council of Turkey TUBITAK TBAG-2259 (102T185) for financial support of this work.en_US
dc.identifier.endpage593en_US
dc.identifier.issn0254-8704
dc.identifier.issue4en_US
dc.identifier.pmid20120501en_US
dc.identifier.startpage591en_US
dc.identifier.urihttps://hdl.handle.net/11616/104418
dc.identifier.volume30en_US
dc.identifier.wosWOS:000267957000020en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTriveni Enterprisesen_US
dc.relation.ispartofJournal of Environmental Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDMBAen_US
dc.subjectLiveren_US
dc.subjectNitric oxideen_US
dc.subjectRat and synthetic organoselenium compoundsen_US
dc.titleThe effects of synthetic organoselenium compounds on nitric oxide in DMBA - induced rat liveren_US
dc.typeArticleen_US

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