Combined usage of estrogen and melatonin restores bladder contractility and reduces kidney and bladder damage in ovariectomized and pinealectomized rats

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridAglamis, Erdogan/0000-0002-7497-7573
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidAglamis, Erdogan/AAA-7464-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.contributor.authorTasdemir, S.
dc.contributor.authorTasdemir, C.
dc.contributor.authorVardi, N.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorAglamis, E.
dc.contributor.authorAtes, B.
dc.contributor.authorSagir, M.
dc.date.accessioned2024-08-04T20:57:26Z
dc.date.available2024-08-04T20:57:26Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The incidence of urinary bladder disturbances and renal structural changes and functional decline are found to increase with age. Methods: We investigated the effect of melatonin treatment in addition to estrogen replacement therapy in pine-alectomized (Px) and ovariectomized (Ovx) rats. 56 female Wistar rats were divided into seven groups, each containing eight animals: Sham, (Ovx), (Px), Px+Ovx, Px+Ovx receiving estrogen (Px+Ovx+E), Px+Ovx receiving melatonin (Px+Ovx+M) and Px+Ovx estrogen and melatonin supplemented (Px+Ovx+EM) group (EM group). We evaluated reduced glutathione (GSH) levels and malondialdehyde (MDA) levels. The mean collagen fiber (CF)/smooth muscle (SM) ratio in the bladder wall and structure of the kidney were examined histolologically. We aleso recorded response of the bladder contractility to acetylcholine (Ach). Results: Px and Ovx groups showed statistically significant reductions of antioxidant defenses, impaired Ach-evoked contraction, histological changes compared with the control group. Also, these changes were prominent in Px+Ovx group compared with all other groups. Both estrogen and melatonin reversed these changes however best restoration was observed in the EM group. Conclusions: Px performed in addition to Ovx led to a distinct increase in oxidative damage in bladder and renal tissue and deteriorate of the detrussor function. Either estradiol or melatonin replacement alone or in combination prevents significant alterations of tissue histology and bladder contractility following Ovx and Px. Thus, combination treatment appears to be the best method to restore both contractility and histomorphology of bladder and kidney tissues after Ovx and Px (Tab. 3, Fig. 4, Ref. 44). Text in PDF www.elis.sk.en_US
dc.description.sponsorshipScientific Research Fund of Inonu University, Turkeyen_US
dc.description.sponsorshipThis project was supported by a Grant from Scientific Research Fund of Inonu University, Turkey.en_US
dc.identifier.doi10.4149/BLL_2014_068
dc.identifier.endpage351en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue6en_US
dc.identifier.pmid25023424en_US
dc.identifier.startpage345en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2014_068
dc.identifier.urihttps://hdl.handle.net/11616/102624
dc.identifier.volume115en_US
dc.identifier.wosWOS:000339087300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpinealectomyen_US
dc.subjectovariectomyen_US
dc.subjectestrogenen_US
dc.subjectmelatoninen_US
dc.subjectbladderen_US
dc.subjectkidneyen_US
dc.titleCombined usage of estrogen and melatonin restores bladder contractility and reduces kidney and bladder damage in ovariectomized and pinealectomized ratsen_US
dc.typeArticleen_US

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