COMBINED IMMUNOSUPPRESSIVE THERAPY IN APLASTIC-ANEMIA

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dc.contributor.authorOSMAN, I
dc.contributor.authorKOC, H
dc.contributor.authorISMET, A
dc.contributor.authorMERAL, B
dc.contributor.authorHAMDI, A
dc.contributor.authorNAHIDE, K
dc.contributor.authorAKIN, U
dc.date.accessioned2024-08-04T20:57:26Z
dc.date.available2024-08-04T20:57:26Z
dc.date.issued1995
dc.departmentİnönü Üniversitesien_US
dc.description.abstractFifteen patients with aplastic anaemia (AA) were treated with combined immunosuppressive treatment (9 of them had severe, the others had less severe AA). Cyclosporin A(CsA) was given as 12 mg/kg/daily intravenous infusions for 90 days with serum levels being monitored weekly by radioimmunoassay. Antilymphocyte globulin serum (ALG) was administered by intravenous infusion through eight hours at a dosage of 20 mg/kg/daily for eight days. Methylprednisolone (MP) was given orally as 5 mg/kg/daily, tapered every three days, for 29 days. Complete remission (CR) was observed in five severe AA patients and two less severe AA patients with therapy. Partial remission (PR) was observed in one severe AA and two less severe AA patients. No remissions were reached in four patients, two of whom had severe AA, the others had less severe AA. Relapse was observed in two patients at sixth and ninth month. Haemolysis occurred in one patient and MP was started. Only one patient died during the treatment because of infection due to febrile neutropaenia. Toxicities were reversible. Combined immunosuppressive treatment may be the treatment of choice for patients who are not eligible for bone marrow transplantation.en_US
dc.identifier.endpage146en_US
dc.identifier.issn0971-5916
dc.identifier.pmid8543355en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://hdl.handle.net/11616/102622
dc.identifier.volume102en_US
dc.identifier.wosWOS:A1995TB25300009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIndian Council Medical Resen_US
dc.relation.ispartofIndian Journal of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectANTILYMPHOCYTE GLOBULINen_US
dc.subjectAPLASTIC ANEMIAen_US
dc.subjectBONE MARROW TRANSPLANTATIONen_US
dc.subjectCYCLOSPORINE-Aen_US
dc.subjectIMMUNOSUPPRESSIVE THERAPY METHYLPREDNISOLONEen_US
dc.titleCOMBINED IMMUNOSUPPRESSIVE THERAPY IN APLASTIC-ANEMIAen_US
dc.typeArticleen_US

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