Comparision of clinical and histopathological results of hyalomatrix usage in adult patients

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dc.authoridAYDIN, Nasuhi/0000-0003-3145-2432
dc.authorwosidAYDIN, Nasuhi/O-9043-2016
dc.contributor.authorErbatur, Serkan
dc.contributor.authorCoban, Yusuf Kenan
dc.contributor.authorAydin, Engin Nasuhi
dc.date.accessioned2024-08-04T20:57:27Z
dc.date.available2024-08-04T20:57:27Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractClinical and histopathological results of the hyaluronic acid skin substitute treatment of the patients who admitted to Inonu University Medical Faculty Plastic Reconstructive and Aesthetic Surgery clinic between january 2011 and march 2012 were evaluated. The patients were divided into two groups. HA were used for treatment of Hypertrophic scar (HS) or Keloid (K) in 10 patients of the first group. Skin biopsies obtained at peroperative and postoperative 3rd month were subjected to histopathologic examination in this group. In the second group, 10 patients with full thickness soft tissue loss secondary to burns, trauma or excisional reasons were also treated with HA application. Vancouver scar scale were used to determine the scar quality in both groups. Mean age was 25. 2 +/- 10.2 and mean follow-up duration was 6.3 +/- 3.6 months in group 1. Preoperative and postoperative VSS scores in group 1 were 10.7 +/- 1.16 and 6.2 +/- 0.91, respectively. This difference was statistically significant (p<0,005). No HS or K development was seen in any patient in group 2 during the following period. Collagenisation scores of preoperative skin biopsies were significantly higher than postoperative scores (p<0,0001). Vascularisation scores of preoperative skin biopsies were significantly lower than postoperative scores (p<0,00001). The use of HA skin substitute in adults for treatment of HS or K provided the desired clinical healing in the 6 months' follow-up periods. At the same time, HA application as an alternative to other treatment modalities led to a durable skin coverage in full thickness tissue loss in adult patients.en_US
dc.identifier.endpage125en_US
dc.identifier.issn2160-2026
dc.identifier.issue2en_US
dc.identifier.pmid23071910en_US
dc.identifier.startpage118en_US
dc.identifier.urihttps://hdl.handle.net/11616/102640
dc.identifier.volume2en_US
dc.identifier.wosWOS:000218881300007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Burns and Traumaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypertrophic scaren_US
dc.subjecthyalomatrixen_US
dc.subjectwound healingen_US
dc.titleComparision of clinical and histopathological results of hyalomatrix usage in adult patientsen_US
dc.typeArticleen_US

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