Effects of Different Progesterone Doses on the Concentrations of Proinflammatory and Anti-inflammatory Cytokines in Pregnant Women With Threatened Abortion

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dc.authoridTanriverdi, Elif Seren/0000-0002-0449-0356
dc.authorwosidTanriverdi, Elif Seren/ABE-4472-2021
dc.contributor.authorKirici, Pinar
dc.contributor.authorTanriverdi, Elif Seren
dc.date.accessioned2024-08-04T20:58:32Z
dc.date.available2024-08-04T20:58:32Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objective This study aimed to investigate how different doses of progesterone influence the concentrations of interleukin-6 (IL-6) and tumor necrotizing factor-alpha (TNF-alpha), which are proinflammatory cytokines, as well as that of IL-10, which is an anti-inflammatory cytokine, in pregnant women with threatened abortion. Materials and methods This is a prospective, single-center, randomized controlled trial conducted with 221 patients with a threatened abortion diagnosis. Group 1 consisted of IL-6, IL-10, and TNF-alpha values in pre-treatment blood samples from 221 patients diagnosed with imminent abortion. Group 2 included 81 patients who received natural oral 100 mg micronized progesterone MP twice a day for two weeks. Group 3 included 83 patients who were administered oral 200 mg of natural micronized progesterone MP twice a day for two weeks. Group 4 included 57 patients who received oral 200 mg of natural micronized progesterone MP twice a day for two weeks, and one depot progesterone was added to the treatment by administering it at a dosage of 500 mg/day intramuscularly. Results IL-6 values between groups were lower in group 4 compared to group 3 (p=0.007). When IL-10 values were compared between the groups, the IL-10 ratio was highest in group 4 and lowest in group 2 (p<0.001, p=0.003, p<0.001). When the TNF-alpha values between the groups were compared, the value in group 4 was decreased compared to groups 1 and 2 (p=0.031, p<0.001). In the logistic regression analysis, the IL-6 value above 12.01 increased the abortion imminens rate 1.01 times, and a TNF-alpha value above 11.04 increased the abortion imminens rate 1.21 times. Conclusion Progesterone used to treat imminent abortion reduces the levels of proinflammatory cytokines, such as IL-6 and TNF-alpha, while increasing those of anti-inflammatory cytokine IL-10 in proportion to the dose administered. Progesterone can prevent imminent abortion by generating an anti-inflammatory environment.en_US
dc.identifier.doi10.7759/cureus.19333
dc.identifier.issn2168-8184
dc.identifier.issue11en_US
dc.identifier.pmid34909296en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.19333
dc.identifier.urihttps://hdl.handle.net/11616/102943
dc.identifier.volume13en_US
dc.identifier.wosWOS:000717955200013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofCureus Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectrandomised clinical trialen_US
dc.subjecttnf-alphaen_US
dc.subjectil-6en_US
dc.subjectil-10en_US
dc.subjectserum progesteroneen_US
dc.subjectthreatened miscarriageen_US
dc.titleEffects of Different Progesterone Doses on the Concentrations of Proinflammatory and Anti-inflammatory Cytokines in Pregnant Women With Threatened Abortionen_US
dc.typeArticleen_US

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