Effects of transforming growth factor-beta 2, interleukin 6 and fibronectin on corneal epithelial wound healing

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dc.contributor.authorEr, H
dc.contributor.authorUzmez, E
dc.date.accessioned2024-08-04T20:58:37Z
dc.date.available2024-08-04T20:58:37Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose. The aim of this study was to compare the effects of topically applied transforming growth factor-beta 2 (TGF-beta 2) and interleukin 6 (IL-6), alone and combined with fibronectin, on the rate of corneal wound healing in rabbits. Methods. Twenty-eight rabbits were used for the experiment. After the right eye of each rabbit was debrided with n-heptyl alcohol, the animals were divided into four treatment groups (six rabbits per group) and one control group (four rabbits). The debrided eyes were treated, beginning immediately after wounding and continuing every 2 hours from 8 a.m. to 8 p.m. for 48 hours. Group 1 received TGF-beta 2; group 2 IL-6; group 3, TFR-beta 2 and purified fibronectin; group 4, IL-6 and fibronectin; control group, balanced salt solution. At set intervals each eye was stained with fluorescein and photographed; epithelial defects were measured with a computer-assisted digitizer. The healing rate was calculated by linear regression analysis. Results. The mean healing rates in groups 1, 2, 3, 4, and controls were respectively 1.65 +/- 0.16, 1.68 +/- 0.11, 1.99 +/- 0.12, 2.23 +/- 0.09, and 0.93 +/- 0.18 mm(2)/h. Mean epithelial healing rates for all drug-treatment groups were significantly faster than controls. The healing rates of groups 3 and 4 were significantly faster than groups 1 and 2. Conclusions. We conclude that cytokines, in combination with extracellular matrix proteins, facilitate corneal epithelial wound healing in vivo, possibly by making corneal epithelial cells more sensitive to fibronectin receptors.en_US
dc.identifier.doi10.1177/112067219800800404
dc.identifier.endpage229en_US
dc.identifier.issn1120-6721
dc.identifier.issn1724-6016
dc.identifier.issue4en_US
dc.identifier.pmid9891893en_US
dc.identifier.startpage224en_US
dc.identifier.urihttps://doi.org/10.1177/112067219800800404
dc.identifier.urihttps://hdl.handle.net/11616/103005
dc.identifier.volume8en_US
dc.identifier.wosWOS:000077895300004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofEuropean Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcorneal wound healingen_US
dc.subjectcytokinesen_US
dc.subjectgrowth factorsen_US
dc.titleEffects of transforming growth factor-beta 2, interleukin 6 and fibronectin on corneal epithelial wound healingen_US
dc.typeArticleen_US

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