Protective effect of melatonin against oxidative stress on adhesion formation in the rat cecum and uterine horn model

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dc.authorid109416en_US
dc.contributor.authorAra, Cengiz
dc.contributor.authorKırımlıoğlu, Saime Hale
dc.contributor.authorBay Karabulut, Aysun
dc.contributor.authorÇoban, Sacid Abdussamet
dc.contributor.authorHasçalık, Şeyma
dc.contributor.authorÇelik, Önder
dc.contributor.authorYılmaz, Sezai
dc.contributor.authorKırımlıoğlu, Vedat
dc.date.accessioned2017-09-08T12:10:20Z
dc.date.available2017-09-08T12:10:20Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis experimental study was designed to evaluate the degree of adhesion formation and peritoneal tissue levels of malondialdehyde (MDA), reduced glutathione (GSH) and nitric oxide (NO) and the effect of melatonin on these metabolites in a postoperative intraperitoneal adhesion formation model in rats. Thirty adult female Wistar albino rats were subjected to standardized lesions by cecal and uterine horn abrasion and were randomly divided into three groups. Control rats were treated with 5% ethanol. Melatonin treated rats received 4 mg/kg melatonin before closure and for 10 consecutive days intraperitoneally after surgery. Rats in the sham operation group underwent a surgical procedure similar to the other groups however the peritoneal abrasion was not performed. On postoperative day 10 relaparatomy was performed. After the assessment of the adhesions, the rats in each group were sacrificed and peritoneal tissues were harvested to determine the tissue levels of MDA, GSH and NO activity. Adhesion formation scores in the melatonin group were significantly lower than that of control and sham group ( p b0.01 and p b0.02, respectively). Tissue levels of MDA and NO were significantly lower in the melatonin treated rats when compared with control and sham groups. The levels of GSH in the melatonin treated rats were significantly higher than those of control and sham groups ( p b0.01). The results demonstrate that in this experimental model, intraperitoneal administration of melatonin decreases the extent of peritoneal adhesions and causes a decrease in MDA and NO and an increase in GSH levels.en_US
dc.identifier.citationAra, C. Kırımlıoğlu, S. H. Bay Karabulut, A. Çoban, S. A. Hasçalık, Ş. Çelik, Ö. Yılmaz, S. Kırımlıoğlu, V. (2005). Protective effect of melatonin against oxidative stress on adhesion formation in the rat cecum and uterine horn model. Life Sci.77 ; 1341 – 1350.en_US
dc.identifier.doi10.1016/j.lfs.2005.01.024en_US
dc.identifier.endpage1350en_US
dc.identifier.startpage1341en_US
dc.identifier.urihttps://hdl.handle.net/11616/7738
dc.identifier.volume77en_US
dc.language.isoenen_US
dc.publisherLife Sci.en_US
dc.relation.ispartofLife Sci.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMelatoninen_US
dc.subjectMalondialdehydeen_US
dc.subjectNitric oxideen_US
dc.subjectReduced glutathioneen_US
dc.subjectAdhesionen_US
dc.titleProtective effect of melatonin against oxidative stress on adhesion formation in the rat cecum and uterine horn modelen_US
dc.typeArticleen_US

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