AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation

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dc.authoridTsatsakis, Aristidis/0000-0003-3824-2462
dc.authoridDocea, Anca Oana/0000-0002-8162-5955
dc.authoridColeman, MIchael D/0000-0002-5510-6852
dc.authorwosidTsatsakis, Aristidis/H-2890-2013
dc.authorwosidDocea, Anca Oana/P-5807-2019
dc.contributor.authorCicek, Betul
dc.contributor.authorHacimuftuoglu, Ahmet
dc.contributor.authorYeni, Yesim
dc.contributor.authorKuzucu, Mehmet
dc.contributor.authorGenc, Sidika
dc.contributor.authorCetin, Ahmet
dc.contributor.authorYavuz, Emre
dc.date.accessioned2024-08-04T20:57:13Z
dc.date.available2024-08-04T20:57:13Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO2) for 21 days. 10 mu g/g AuNPs, 1.6 g/kg CS, and 10 mu g/g CS-AuNPs were administered orally simultaneously with 10 mg/ kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-alpha and IL-1 beta levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments.en_US
dc.description.sponsorshipEuropean Union 's Horizon Europe framework program project 'European Partnership for the Assessment of Risks from Chemicals (PARC)en_US
dc.description.sponsorshipThe present study was partly funded by the European Union 's Horizon Europe framework program project 'European Partnership for the Assessment of Risks from Chemicals (PARC) .en_US
dc.identifier.doi10.1016/j.etap.2024.104417
dc.identifier.issn1382-6689
dc.identifier.issn1872-7077
dc.identifier.pmid38493879en_US
dc.identifier.urihttps://doi.org/10.1016/j.etap.2024.104417
dc.identifier.urihttps://hdl.handle.net/11616/102444
dc.identifier.volume107en_US
dc.identifier.wosWOS:001223389200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEnvironmental Toxicology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAuNPsen_US
dc.subjectArsenicen_US
dc.subjectCynara scolymusen_US
dc.subjectNeurotoxicityen_US
dc.subjectD1Ren_US
dc.subjectD2Ren_US
dc.titleAuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activationen_US
dc.typeArticleen_US

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