Paricalcitol inhibits the wnt/beta-catenin signaling pathway and ameliorates experimentally inducedarthritis

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dc.contributor.authorYolbas, Servet
dc.contributor.authorYildirim, Ahmet
dc.contributor.authorTektemur, Ahmet
dc.contributor.authorCelik, Zulfinaz Betul
dc.contributor.authorOnalan Etem, Ebru
dc.contributor.authorOzercan, Ibrahim Hanifi
dc.contributor.authorAkin, Mehmet Mustafa
dc.contributor.authorKoca, Suleyman Serdar
dc.date.accessioned2019-07-18T08:34:34Z
dc.date.available2019-07-18T08:34:34Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/aim: The Wnt/beta-catenin pathway has important biological activities, including the differentiation of cells and joint formations. The aim of our study was to determine the effect of paricalcitol on experimentally induced arthritis. Materials and methods: Type II collagen combined with Freund's adjuvant was applied to induce arthritis in Wistar albino female rats. Paricalcitol (0.3 mu g/kg daily) was subcutaneously injected starting 1 day after collagen applications (prophylactic group) or 1 day after the onset of arthritis (therapeutic group), until day 29. Results: The 29th day arthritis scores were lower compared to the 13th day scores in the paricalcitol groups (P < 0.05), while they were higher in the arthritis group (P < 0.05). Marked cartilage-bone destruction and extensive perisynovial inflammation were detected in the arthritis group. Decreased cartilage-bone destruction and perisynovial inflammation in the paws were observed in the paricalcitol groups. The tissue mRNA levels of DKK1, Wnt5a, and axin-2 were higher in the arthritis group than in the control group. In the paricalcitol groups, mRNA expressions were lower than in the arthritis group. Conclusion: The present study shows that the Wnt/beta-catenin signaling pathway is active in arthritis. Moreover, paricalcitol ameliorates arthritis via inhibiting the Wnt/beta B-catenin pathway. Paricalcitol and the Wnt/beta-catenin pathway are candidates for research in human rheumatoid arthritis.en_US
dc.identifier.citationYolbas, S. Yildirim, A. Tektemur, A. Celik, ZB . Onalan Etem, E.Ozercan, IH . Akin, MM. Koca, SS. (2018). Paricalcitol inhibits the wnt/beta-catenin signaling pathway and ameliorates experimentally inducedarthritis. Cilt:48. Sayı:5. 1080- 1086 ss.en_US
dc.identifier.doi10.3906/sag-1804-62en_US
dc.identifier.endpage1086en_US
dc.identifier.issue5en_US
dc.identifier.startpage1080en_US
dc.identifier.urihttps://hdl.handle.net/11616/12734
dc.identifier.volume48en_US
dc.language.isoenen_US
dc.publisherTubıtak scıentıfıc & technıcal research councıl turkey, ataturk bulvarı no 221, kavaklıdere, ankara, 00000, turkeyen_US
dc.relation.ispartofTurkısh journal of medıcal scıencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRheumatoıd-arthrıtısen_US
dc.subjectbeta-catenınen_US
dc.subjectexpressıonen_US
dc.subjectboneen_US
dc.subjectınflammatıonen_US
dc.subjectcellsen_US
dc.subjectmodelen_US
dc.subjectmedıatorsen_US
dc.subjectagentsen_US
dc.subjectrolesen_US
dc.titleParicalcitol inhibits the wnt/beta-catenin signaling pathway and ameliorates experimentally inducedarthritisen_US
dc.typeArticleen_US

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